Evidence map›Paper›PMID 31439645›Full record

ArticleDiabetes2019

Severe Hypoglycemia-Induced Fatal Cardiac Arrhythmias Are Mediated by the Parasympathetic Nervous System in Rats.

Candace M Reno, Justin Bayles, Yiqing Huang, Milan Oxspring, Annie M Hirahara, Derek J Dosdall, Simon J Fisher

Open access · bronzeAbstract read
In one paragraph

Article in Diabetes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Strategies for optimization of hypoglycemia rat models.Animal models and experimental medicine · 2025
    Review
  3. Article
  4. Review
  5. Dysglycemia and arrhythmias.World journal of diabetes · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Hypoglycaemia and cardiac arrhythmias in diabetes.Therapeutic advances in endocrinology and metabolism · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Candace M RenoDivision of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, University of Utah, Salt Lake City, UT.
Justin BaylesDivision of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, University of Utah, Salt Lake City, UT.
Yiqing HuangDivision of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, University of Utah, Salt Lake City, UT.
Milan OxspringDivision of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, University of Utah, Salt Lake City, UT.
Annie M HiraharaNora Eccles Harrison Cardiovascular Research & Training Institute, University of Utah, Salt Lake City, UT.
Derek J DosdallNora Eccles Harrison Cardiovascular Research & Training Institute, University of Utah, Salt Lake City, UT.
Simon J FisherDivision of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, University of Utah, Salt Lake City, UT sfisher@u2m2.utah.edu.ORCID 0000-0002-5228-2594
University of Utah · US

Funding

His-Purkinje Pacing for Low Energy Implantable Cardioverter DefibrillatorsR01HL128752 · NHLBI · UNIVERSITY OF UTAH · PI DOSDALL, DEREK J · 2015 to 2024
$5.0M
Interdisciplinary Training Program in MetabolismT32DK091317 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI SCOTT A SUMMERS · 2011 to 2026
$4.8M
Pharmacological Approach to the Restoration of Hypoglycemia AwarenessR01DK118082 · NIDDK · UNIVERSITY OF UTAH · PI FISHER, SIMON J · 2019 to 2023
$1.9M
DIABETES ASSOCIATED BRAIN DAMAGE FOLLOWING SEVERE HYPOGLYCEMIAR01NS070235 · NINDS · WASHINGTON UNIVERSITY · PI FISHER, SIMON J · 2010 to 2014
$1.5M
NHLBI NIH HHS R01 HL128752NIDDK NIH HHS R01 DK118082NIDDK NIH HHS T32 DK091317NINDS NIH HHS R01 NS070235
6 · The paper itself

Abstract

The contribution of the sympathetic nervous system (SNS) versus the parasympathetic nervous system (PSNS) in mediating fatal cardiac arrhythmias during insulin-induced severe hypoglycemia is not well understood. Therefore, experimental protocols were performed in nondiabetic Sprague-Dawley rats to test the SNS with

Indexed as

AnimalsArrhythmias, CardiacBenzodiazepinonesDisease Models, AnimalHypoglycemiaMaleMecamylamineMuscarinic AntagonistsNicotinic AntagonistsParasympathetic Nervous SystemPiperidinesRatsRats, Sprague-DawleySympathectomy, ChemicalVagotomyAQ-RA 741BenzodiazepinonesMecamylamineMuscarinic AntagonistsNicotinic AntagonistsPiperidines

Identifiers

PMID31439645
PMCPMC7118248
OpenAlexW2969321274

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.