Evidence map›Paper›PMID 31439308›Full record

ReviewBritish journal of anaesthesia2019

State of the clinical science of perioperative brain health: report from the American Society of Anesthesiologists Brain Health Initiative Summit 2018.

Elizabeth Mahanna-Gabrielli, Katie J Schenning, Lars I Eriksson, Jeffrey N Browndyke, Clinton B Wright, Deborah J Culley, Lis Evered, David A Scott, Nae Yah Wang, Charles H Brown and 7 more

Erratum issued 2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in British journal of anaesthesia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 114 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05279898 nacompletednot on this mapstarted 2023, after this paper: background citation

Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies - the PATHFINDER II Study

TypeinterventionalSponsorBeth Israel Deaconess Medical CenterRan2023 to 2024Enrolled70ConditionsPostoperative Delirium, Hemodynamic Instability, Pain, Neurocognitive DysfunctionArmsEEG Monitoring, Ropivacaine, Ketamine, Remifentanil, Dexmedetomidine
NCT07523334 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Impact of Esketamine on Delayed Neurocognitive Recovery in Older Patients Undergoing Non-cardiac Surgery: a Two-center, Dose-exploring Pilot Trial

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2026Enrolled120ConditionsElderly, Noncardiac Surgery, Delayed Neurocognitive Recovery, Postoperative DeliriumArmsEsketamine 1, Esketamine 2, Esketamine 3, Normal saline
3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Elizabeth Mahanna-GabrielliDepartment of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Katie J SchenningOregon Health & Science University, Portland, OR, USA.
Lars I ErikssonDepartment of Physiology and Pharmacology, Section for Anaesthesiology and Intensive Care, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Jeffrey N BrowndykeGeriatric Behavioral Health Division, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center and Duke Institute for Brain Sciences, Duke University, Durham, NC, USA.
Clinton B WrightNational Institute of Neurological Disorders, Bethesda, MD, USA.
Deborah J Culley
Lis EveredDepartment of Anaesthesia and Acute Pain Medicine, St Vincent's Hospital Melbourne, Melbourne Medical School, University of Melbourne, Melbourne, Victoria, Australia.
David A ScottDepartment of Anaesthesia and Acute Pain Medicine, St Vincent's Hospital Melbourne, Melbourne Medical School, University of Melbourne, Melbourne, Victoria, Australia.
Nae Yah WangDepartment of Medicine, Biostatistics, and Epidemiology, Department of Anesthesiology and Critical Care Medicine, and Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Charles H BrownDepartment of Medicine, Biostatistics, and Epidemiology, Department of Anesthesiology and Critical Care Medicine, and Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Esther OhDepartment of Medicine, Biostatistics, and Epidemiology, Department of Anesthesiology and Critical Care Medicine, and Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Patrick PurdonDepartment of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.
Sharon InouyeAging Brain Center at the Hinda and Arthur Marcus Institute for Aging Research, Hebrew Senior Life, Harvard Medical School, Beth Israel Deaconess, Boston, MA, USA.
Miles BergerDepartment of Anesthesiology, Duke Center for Cognitive Neuroscience, Duke Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC, USA.
Robert A WhittingtonVagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Catherine C Price
Stacie DeinerDepartments of Anesthesiology, Perioperative and Pain Medicine, Geriatrics and Palliative Care, and Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: stacie.deiner@mountsinai.org.

Funding

Physician Postdoctoral Research Training in Perioperative Medicine (PPRTPM)T32GM112596 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Roderic G Eckenhoff, Max Kelz · 2015 to 2026
$3.4M
Optimizing postoperative cognition in the elderlyK23AG048332 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DEINER, STACIE · 2015 to 2019
$847k
NIA NIH HHS K23 AG048332NIGMS NIH HHS T32 GM112596
6 · The paper itself

Abstract

Cognitive recovery after anaesthesia and surgery is a concern for older adults, their families, and caregivers. Reports of patients who were 'never the same' prompted a scientific inquiry into the nature of what patients have experienced. In June 2018, the ASA Brain Health Initiative held a summit to discuss the state of the science on perioperative cognition, and to create an implementation plan for patients and providers leveraging the current evidence. This group included representatives from the AARP (formerly the American Association of Retired Persons), American College of Surgeons, American Heart Association, and Alzheimer's Association Perioperative Cognition and Delirium Professional Interest Area. This paper summarises the state of the relevant clinical science, including risk factors, identification and diagnosis, prognosis, disparities, outcomes, and treatment of perioperative neurocognitive disorders. Finally, we discuss gaps in current knowledge with suggestions for future directions and opportunities for clinical and translational projects.

Indexed as

AgedAged, 80 and overAnesthesiaAnesthesiologyBrainCognition DisordersEmergence DeliriumHealth StatusHumansRisk Factorsanaesthesiadeliriumgeriatricsneurocognitive disordersperioperative brain healthpostoperative cognitive dysfunctionpostoperative complications

Identifiers

PMID31439308
PMCPMC6871269

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.