ArticleBMC infectious diseases2019
Clinical profiles of early and tuberculosis-related mortality in South Korea between 2015 and 2017: a cross-sectional study.
Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Tuberculosis-Related Hospitalization According to Comorbidity Burden: A Retrospective Single-Center Cohort Study.Tropical medicine and infectious disease · 2026Article
- The impact of population ageing on tuberculosis incidence, mortality, and case fatality in South Korea: a nationwide retrospective study.ERJ open research · 2025Article
- Nutrition Status and Comorbidities Are Important Factors Associated With Mortality During Anti-Tuberculosis Treatment.Journal of Korean medical science · 2025Observational
- Treatment outcomes of pulmonary TB in adults in Indonesia.IJTLD open · 2025Article
- Factors associated with tuberculosis deaths during hospitalization in Midwest Brazil.Revista do Instituto de Medicina Tropical de Sao Paulo · 2025Article
- Mortality and its influencing factors during anti-tuberculosis treatment in pulmonary tuberculosis patients in Hunan Province.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Article
- Timing and predictors of death during treatment in patients with multidrug/rifampin-resistant tuberculosis in South Korea.The Korean journal of internal medicine · 2024Article
- Retreatment after loss to follow-up reduces mortality in patients with multidrug/rifampicin-resistant tuberculosis.ERJ open research · 2023Article
- Effects of underweight and overweight on mortality in patients with pulmonary tuberculosis.Frontiers in public health · 2023Article
- Deaths from tuberculosis: differences between tuberculosis-related and non-tuberculosis-related deaths.Frontiers in public health · 2023Article
- Screening for Severe Illness at Diagnosis Has the Potential to Prevent Early TB Deaths: Programmatic Experience From Karnataka, India.Global health, science and practice · 2022Article
- Tuberculosis Death Epidemiology and Its Associated Risk Factors in Sabah, Malaysia.International journal of environmental research and public health · 2021Article
- Screening People with Tuberculosis for High Risk of Severe Illness at Notification: Programmatic Experience from Karnataka, India.Tropical medicine and infectious disease · 2021Article
- In-hospital mortality of pulmonary tuberculosis with acute respiratory failure and related clinical risk factors.Journal of clinical tuberculosis and other mycobacterial diseases · 2021Article
- The potential impact of the COVID-19 response related lockdown on TB incidence and mortality in India.The Indian journal of tuberculosis · 2020Review
- Prediction of treatment failure and compliance in patients with tuberculosis.BMC infectious diseases · 2020Article
- Active Pulmonary Tuberculosis in Elderly Patients: A 2016-2019 Retrospective Analysis from an Italian Referral Hospital.Antibiotics (Basel, Switzerland) · 2020Article
- Tuberculosis Surveillance and Monitoring under the National Public-Private Mix Tuberculosis Control Project in South Korea 2016-2017.Tuberculosis and respiratory diseases · 2020Article
- Tuberculosis deaths are predictable and preventable: Comprehensive assessment and clinical care is the key.Journal of clinical tuberculosis and other mycobacterial diseases · 2020Article
- Factors associated with mortality among patients with culture-positive pulmonary tuberculosis in the urban poor population of Osaka City, Japan.Western Pacific surveillance and response journal : WPSARArticle
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Authors and funding
13 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the incidence of tuberculosis (TB) has decreased in South Korea, the mortality rate remains high. TB mortality is a key indicator for TB control interventions. The purpose of this study was to assess early and TB-related mortality during anti-TB treatment and describe the associated clinical characteristics.
methodsA multicenter cross-sectional study was performed across South Korea. Patients with pulmonary TB who died during anti-TB treatment and whose records were submitted to the national TB surveillance system between 2015 and 2017 were enrolled. All TB deaths were categorized based on cause (TB-related or non-TB-related) and timing (early or late). We identified statistical associations using the frequency table, chi-square test, and binary logistic regression.
resultsOf 5595 notifiable mortality cases, 3735 patients with pulmonary TB were included in the analysis. There were 2541 (68.0%) male patients, and 2935 (78.6%) mortality cases were observed in patients older than 65 years. There were 944 (25.3%) cases of TB-related death and 2545 (68.1%) cases of early death. Of all cases, 187 (5.0%) patients were diagnosed post-mortem and 38 (1.0%) patients died on the first day of treatment. Low body mass index (adjusted odds ratio (aOR) = 1.26; 95% confidence interval (CI) = 1.08-1.48), no reported illness (aOR = 1.36; 95% CI = 1.10-1.68), bilateral disease on chest X-ray (aOR = 1.30; 95% CI = 1.11-1.52), and positive acid-fast bacilli smear result (aOR = 1.30; 95% CI = 1.11-1.52) were significantly associated with early death, as well as TB-related death. Acute respiratory failure was the most common mode of non-TB-related death. Malignancy was associated with both late (aOR = 0.71; 95% CI = 0.59-0.89) and non-TB-related (aOR = 0.35; 95% CI = 0.26-0.46) death.
conclusionsA high proportion of TB death was observed in elderly patients and attributed to non-TB-related causes. Many TB-related deaths occurred during the intensive phase, particularly within the first month. Further studies identifying risk factors for different causes of TB death at different phases of anti-TB treatment are warranted for early targeted intervention in order to reduce TB mortality.
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