Evidence map›Paper›PMID 31438869›Full record

ArticleBMC nephrology2019

BMI and its association with death and the initiation of renal replacement therapy (RRT) in a cohort of patients with chronic kidney disease (CKD).

Zaimin Wang, Jianzhen Zhang, Samuel Chan, Anne Cameron, Helen G Healy, Sree K Venuthurupalli, Ken-Soon Tan, Wendy E Hoy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zaimin WangNHMRC CKD.CRE and CKD.QLD, Health Science Building, Level 8, University of Queensland, RBWH, Brisbane, Herston, QLD 4029, Australia. zaimin16@yahoo.com.au.ORCID 0000-0001-7999-9360
Jianzhen ZhangNHMRC CKD.CRE and CKD.QLD, Health Science Building, Level 8, University of Queensland, RBWH, Brisbane, Herston, QLD 4029, Australia.
Samuel ChanNHMRC CKD.CRE and CKD.QLD, Health Science Building, Level 8, University of Queensland, RBWH, Brisbane, Herston, QLD 4029, Australia.
Anne CameronNHMRC CKD.CRE and CKD.QLD, Health Science Building, Level 8, University of Queensland, RBWH, Brisbane, Herston, QLD 4029, Australia.
Helen G HealyNHMRC CKD.CRE and CKD.QLD, Health Science Building, Level 8, University of Queensland, RBWH, Brisbane, Herston, QLD 4029, Australia.
Sree K VenuthurupalliNHMRC CKD.CRE and CKD.QLD, Health Science Building, Level 8, University of Queensland, RBWH, Brisbane, Herston, QLD 4029, Australia.
Ken-Soon TanNHMRC CKD.CRE and CKD.QLD, Health Science Building, Level 8, University of Queensland, RBWH, Brisbane, Herston, QLD 4029, Australia.
Wendy E HoyNHMRC CKD.CRE and CKD.QLD, Health Science Building, Level 8, University of Queensland, RBWH, Brisbane, Herston, QLD 4029, Australia.
The University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA survival advantage associated with obesity has often been described in dialysis patients. The association of higher body mass index (BMI) with mortality and renal replacement therapy (RRT) in preterminal chronic kidney disease (CKD) patients has not been established.

methodsSubjects were patients with pre-terminal CKD who were recruited to the CKD.QLD registry. BMI at time of consent was grouped as normal (BMI 18.5-24.9 kg/m

resultsThe cohort consisted of 3344 CKD patients, of whom 1777 were males (53.1%). The percentages who had normal BMI, or were overweight, mildly obese and moderately obese+ were 18.9, 29.9, 25.1 and 26.1%, respectively. Using people with normal BMI as the reference group, and after adjusting for age, socio-economic status, CKD stage, primary renal diagnoses, comorbidities including cancer, diabetes, peripheral vascular disease (PVD), chronic lung disease, coronary artery disease (CAD), and all other cardiovascular disease (CVD), the hazard ratios (HRs, 95% CI) of males for death without RRT were 0.65 (0.45-0.92, p = 0.016), 0.60 (0.40-0.90, p = 0.013), and 0.77 (0.50-1.19, p = 0.239) for the overweight, mildly obese and moderately obese+. With the same adjustments the hazard ratios for death without RRT in females were 0.96 (0.62-1.50, p = 0.864), 0.94 (0.59-1.49, p = 0.792) and 0.96 (0.60-1.53, p = 0.865) respectively. In males, with normal BMI as the reference group, the adjusted HRs of starting RRT were 1.15 (0.71-1.86, p = 0.579), 0.99 (0.59-1.66, p = 0.970), and 0.95 (0.56-1.61, p = 0.858) for the overweight, mildly obese and moderately obese+ groups, respectively, and in females they were 0.88 (0.44-1.76, p = 0.727), 0.94 (0.47-1.88, p = 0.862) and 0.65 (0.33-1.29, p = 0.219) respectively.

conclusionsMore than 80% of these CKD patients were overweight or obese. Higher BMI seemed to be a significant "protective" factor against death without RRT in males but there was not a significant relationship in females. Higher BMI was not a risk factor for predicting RRT in either male or female patients with CKD.

Indexed as

Body Mass IndexRenal Replacement TherapyAdolescentAdultAgedAged, 80 and overAge FactorsCause of DeathCohort StudiesComorbidityFemaleHumansIncidenceKaplan-Meier EstimateKidney Failure, ChronicMaleBMIChronic kidney diseaseEpidemiologyMortalityObesityRRT

Identifiers

PMID31438869
PMCPMC6704588
OpenAlexW2969886165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.