ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2019
The innovation of the final moult and the origin of insect metamorphosis.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 67 citations in OpenAlex.
- Rewiring of two conserved signalling hubs into one axis underlies convergent female-specific wing regression in insects.Nature ecology & evolution · 2026Article
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- Krüppel homolog 1, a juvenile hormone transcription factor, regulates the reproduction and development of Aedes albopictus(Skuse) (Diptera: Culicidae).Parasitology research · 2025Article
- Developmental correspondence of juvenile stages across the locust, harlequin ladybird, and diamondback moth.iScience · 2024Article
- Juvenile hormone signaling is indispensable for late embryogenesis in ametabolous and hemimetabolous insects.BMC biology · 2024Article
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- Pri peptides temporally coordinate transcriptional programs during epidermal differentiation.Science advances · 2024Article
- The embryonic role of juvenile hormone in the firebrat,bioRxiv : the preprint server for biology · 2024Article
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- The function of wing bullae in mayflies (Insecta: Ephemeroptera) reveals new insights into the early evolution of Pterygota.BMC biology · 2023Article
- The making of a maggot brain.eLife · 2023Article
- Reduction of embryonicProceedings of the National Academy of Sciences of the United States of America · 2023Article
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- Drosophila E93 promotes adult development and suppresses larval responses to ecdysone during metamorphosis.Developmental biology · 2022Article
- Review
- Krüppel-homolog 1 exerts anti-metamorphic and vitellogenic functions in insects via phosphorylation-mediated recruitment of specific cofactors.BMC biology · 2021Article
- Mayfly metamorphosis: Adult winged insects that molt.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Regulation of metamorphosis in neopteran insects is conserved in the paleopteranProceedings of the National Academy of Sciences of the United States of America · 2021Article
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1 author at 1 institution in 1 country.
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Abstract
The three modes of insect postembryonic development are ametaboly, hemimetaboly and holometaboly, the latter being considered the only significant metamorphosis mode. However, the emergence of hemimetaboly, with the genuine innovation of the final moult, represents the origin of insect metamorphosis and a necessary step in the evolution of holometaboly. Hemimetaboly derives from ametaboly and might have appeared as a consequence of wing emergence in Pterygota, in the early Devonian. In extant insects, the final moult is mainly achieved through the degeneration of the prothoracic gland (PG), after the formation of the winged and reproductively competent adult stage. Metamorphosis, including the formation of the mature wings and the degeneration of the PG, is regulated by the MEKRE93 pathway, through which juvenile hormone precludes the adult morphogenesis by repressing the expression of transcription factor E93, which triggers this change. The MEKRE93 pathway appears conserved in extant metamorphosing insects, which suggest that this pathway was operative in the Pterygota last common ancestor. We propose that the final moult, and the consequent hemimetabolan metamorphosis, is a monophyletic innovation and that the role of E93 as a promoter of wing formation and the degeneration of the PG was mechanistically crucial for their emergence. This article is part of the theme issue 'The evolution of complete metamorphosis'.
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