ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2019
Immune gene regulation in the gut during metamorphosis in a holo- versus a hemimetabolous insect.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Multifunctional lysozymes from the assassin bug Sycanus bifidus: Insecticidal proteins with anticoagulant and melanization inhibition properties.Pest management science · 2026Article
- Genome-Wide Identification of Transcriptional Start Sites and Candidate Enhancers Regulating Worker Metamorphosis inInsects · 2026Article
- Review
- Altruistic disease signalling in ant colonies.Nature communications · 2025Article
- Steroid hormone regulation of innate immunity in Drosophila melanogaster.PLoS genetics · 2023Review
- Microbiota is structured by gut regions, life stage, and diet in the Black Soldier Fly (Frontiers in microbiology · 2023Article
- In the battle of the disease: a transcriptomic analysis of European foulbrood-diseased larvae of the Western honey bee (Apis mellifera).BMC genomics · 2022Article
- Induction of Multiple Immune Signaling Pathways inViruses · 2022Article
- Role of Insect Gut Microbiota in Pesticide Degradation: A Review.Frontiers in microbiology · 2022Review
- Co-option of immune effectors by the hormonal signalling system triggering metamorphosis in Drosophila melanogaster.PLoS genetics · 2021Article
- Bacteria primed by antimicrobial peptides develop tolerance and persist.PLoS pathogens · 2021Article
- Metagenomic Survey of the Highly PolyphagousFrontiers in microbiology · 2021Article
- The Role of Bacterial Symbionts in Triatomines: An Evolutionary Perspective.Microorganisms · 2020Review
- Links between metamorphosis and symbiosis in holometabolous insects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Antipredator strategies of pupae: how to avoid predation in an immobile life stage?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- The legacy of larval infection on immunological dynamics over metamorphosis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Complete metamorphosis of insects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Evaluating responses to temperature during pre-metamorphosis and carry-over effects at post-metamorphosis in the wood tiger moth (Arctia plantaginis).Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
During metamorphosis, holometabolous insects completely replace the larval gut and must control the microbiota to avoid septicaemia. Rapid induction of bactericidal activity in the insect gut at the onset of pupation has been described in numerous orders of the Holometabola and is best-studied in the Lepidoptera where it is under control of the 20-hydroxyecdysone (20E) moulting pathway. Here, using RNAseq, we compare the expression of immune effector genes in the gut during metamorphosis in a holometabolous (Galleria mellonella) and a hemimetabolous insect (Gryllus bimaculatus). We find that in G. mellonella, the expression of numerous immune effectors and the transcription factor GmEts are upregulated, with peak expression of three antimicrobial peptides (AMPs) and a lysozyme coinciding with delamination of the larval gut. By contrast, no such upregulation was detectable in the hemimetabolous Gr. bimaculatus. These findings support the idea that the upregulation of immune effectors at the onset of complete metamorphosis is an adaptive response, which controls the microbiota during gut replacement. This article is part of the theme issue 'The evolution of complete metamorphosis'.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.