ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2019
The evolution of insect metamorphosis: a developmental and endocrine view.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.
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81 citing papers in PubMed, 1 synthesis or guideline pooled it, 187 citations in OpenAlex.
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- Stage-Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Zona pellucida proteins Piopio and Dumpy are essential for the apical extracellular matrix assembly and survival of Locusta migratoria.Pest management science · 2026Article
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- Functional spatial organization of antennal hair plate sensilla and their development in crickets.Cell and tissue research · 2026Article
- Isoform-resolved transcriptomics reveals stage-specific isoform switching and protein domain remodeling inTranscription · 2026Article
- Resource Availability Modulates Gene Expression Across Life Stages in a Migratory Butterfly.Molecular ecology · 2026Article
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- Transcriptome analysis of perforated small cocoon from Bombyx mori mutants.Scientific reports · 2026Article
- Characterization of the Crustacean Methyl Farnesoate Transcriptional Signaling Genes.International journal of molecular sciences · 2026Article
- A Proteomic View of Butterfly Metamorphosis.Proteomes · 2025Article
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- Whole organism integrated DNA methylation and transcriptomics analysis of butterfly metamorphosis.Scientific reports · 2025Article
- SUMOylation modulates the dual functions of Krüppel homolog 1 in transcriptional regulation of Broad-Complex expression.Journal of advanced research · 2025Article
- When and how do 17-year periodical cicada nymphs decide to emerge? A field test of the 4-year-gate hypothesis.Proceedings. Biological sciences · 2025Article
- Chromatin Accessibility Dynamics Reveal Conserved Transcriptional Regulatory Networks During Insect Metamorphosis inBiology · 2025Article
- Do the "big four" orders of insects comprise evolutionarily significant higher taxa with coherent patterns of selection on protein-coding genes?Evolution letters · 2025Article
21 more citing papers are in PubMed but not listed here.
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2 authors at 1 institution in 1 country.
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Abstract
Developmental, genetic and endocrine data from diverse taxa provide insight into the evolution of insect metamorphosis. We equate the larva-pupa-adult of the Holometabola to the pronymph-nymph-adult of hemimetabolous insects. The hemimetabolous pronymph is a cryptic embryonic stage with unique endocrinology and behavioural modifications that probably served as preadaptations for the larva. It develops in the absence of juvenile hormone (JH) as embryonic primordia undergo patterning and morphogenesis, the processes that were arrested for the evolution of the larva. Embryonic JH then drives tissue differentiation and nymph formation. Experimental treatment of pronymphs with JH terminates patterning and induces differentiation, mimicking the processes that occurred during the evolution of the larva. Unpatterned portions of primordia persist in the larva, becoming imaginal discs that form pupal and adult structures. Key transcription factors are associated with the holometabolous life stages: Krüppel-homolog 1 (Kr-h1) in the larva, broad in the pupa and E93 in the adult. Kr-h1 mediates JH action and is found whenever JH acts, while the other two genes direct the formation of their corresponding stages. In hemimetabolous forms, the pronymph has low Broad expression, followed by Broad expression through the nymphal moults, then a switch to E93 to form the adult. This article is part of the theme issue 'The evolution of complete metamorphosis'.
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