ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2019
The legacy of larval infection on immunological dynamics over metamorphosis.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Resources Modulate Developmental Shifts but Not Infection Tolerance Upon Co-Infection in an Insect System.Molecular ecology · 2025Article
- Impact ofInsects · 2025Article
- MyD88 knockdown by RNAi prevents bacterial stimulation of tubeworm metamorphosis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Juvenile responses to immune challenges are not carried through to subsequent life stages in an insect.Scientific reports · 2024Article
- The link between gene duplication and divergent patterns of gene expression across a complex life cycle.Evolution letters · 2024Article
- Resources modulate developmental shifts but not infection tolerance upon coinfection in an insect system.bioRxiv : the preprint server for biology · 2024Article
- Cereal weevils' antimicrobial peptides: at the crosstalk between development, endosymbiosis and immune response.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Mapping the functional form of the trade-off between infection resistance and reproductive fitness under dysregulated immune signaling.PLoS pathogens · 2024Article
- Article
- The Evolution of the Age of Onset of Resistance to Infectious Disease.Bulletin of mathematical biology · 2023Article
- The Effect of Developmental Pleiotropy on the Evolution of Insect Immune Genes.Genome biology and evolution · 2023Article
- Expression of Immunity- and Stress-Related Genes during an Intermolt Period in the Colorado Potato Beetle.Insects · 2022Article
- Article
- DoesInsects · 2022Article
- Article
- Article
- Links between metamorphosis and symbiosis in holometabolous insects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Antipredator strategies of pupae: how to avoid predation in an immobile life stage?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Immune gene regulation in the gut during metamorphosis in a holo- versus a hemimetabolous insect.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Complete metamorphosis of insects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
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3 authors.
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Abstract
Insect metamorphosis promotes the exploration of different ecological niches, as well as exposure to different parasites, across life stages. Adaptation should favour immune responses that are tailored to specific microbial threats, with the potential for metamorphosis to decouple the underlying genetic or physiological basis of immune responses in each stage. However, we do not have a good understanding of how early-life exposure to parasites influences immune responses in subsequent life stages. Is there a developmental legacy of larval infection in holometabolous insect hosts? To address this question, we exposed flour beetle (Tribolium castaneum) larvae to a protozoan parasite that inhabits the midgut of larvae and adults despite clearance during metamorphosis. We quantified the expression of relevant immune genes in the gut and whole body of exposed and unexposed individuals during the larval, pupal and adult stages. Our results suggest that parasite exposure induces the differential expression of several immune genes in the larval stage that persist into subsequent stages. We also demonstrate that immune gene expression covariance is partially decoupled among tissues and life stages. These results suggest that larval infection can leave a lasting imprint on immune phenotypes, with implications for the evolution of metamorphosis and immune systems. This article is part of the theme issue 'The evolution of complete metamorphosis'.
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