Evidence map›Paper›PMID 31438773›Full record

ArticleTissue barriers2019

Differential gene expression and gene-set enrichment analysis in Caco-2 monolayers during a 30-day timeline with Dexamethasone exposure.

J M Robinson, S Turkington, S A Abey, N Kenea, W A Henderson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue barriers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Resilience of lung grafts to warm ischemia: assessment byTransplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

J M RobinsonDigestive Disorder Unit, Biobehavioral Branch, Division of Intramural Research, National Institute of Nursing Research (NINR), NIH, DHHS , Bethesda , MD , USA.ORCID 0000-0002-1456-2851
S TurkingtonDigestive Disorder Unit, Biobehavioral Branch, Division of Intramural Research, National Institute of Nursing Research (NINR), NIH, DHHS , Bethesda , MD , USA.
S A AbeyDigestive Disorder Unit, Biobehavioral Branch, Division of Intramural Research, National Institute of Nursing Research (NINR), NIH, DHHS , Bethesda , MD , USA.
N KeneaDigestive Disorder Unit, Biobehavioral Branch, Division of Intramural Research, National Institute of Nursing Research (NINR), NIH, DHHS , Bethesda , MD , USA.
W A HendersonDigestive Disorder Unit, Biobehavioral Branch, Division of Intramural Research, National Institute of Nursing Research (NINR), NIH, DHHS , Bethesda , MD , USA.ORCID 0000-0003-3924-7118
National Institute of Nursing Research · US

Funding

Symptom Distress Mechanisms in Digestive DisordersZIANR000018 · NINR · NATIONAL INSTITUTE OF NURSING RESEARCH · PI HENDERSON, WENDY · 2009 to 2019
$5.2M
Intramural NIH HHS ZIA NR000018
6 · The paper itself

Abstract

Glucocorticoid hormones affect gene expression via activation of glucocorticoid receptor NR3C1, causing modulation of inflammation and autoimmune activation. The glucocorticoid Dexamethasone is an important pharmaceutical for the treatment of colitis and other inflammatory bowel diseases. While suppressive effects of glucocorticoids on activated immune cells is significant, their effects upon epithelial cells are less well studied. Previous research shows that the effects of Dexamethasone treatment on polarized Caco-2 cell layer permeability is delayed for >10 treatment days (as measured by transepithelial electrical resistance).

Indexed as

Caco-2 CellsCytoskeletonDexamethasoneGene ExpressionHumansTime FactorsDexamethasoneCaco-2Dexamethasoneepithelial barrier functionEpithelial homeostasisepithelial permeabilityglucocorticoidNanoStringRhoGTPaseTEERtight junction

Identifiers

PMID31438773
PMCPMC6748367
OpenAlexW2969736863

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.