ArticlePolymers2019
Analysis of Drug Release Behavior Utilizing the Swelling Characteristics of Cellulosic Nanofibers.
Article in Polymers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Fabrication and characterization of prednisolone acetate-loaded electrospun mucoadhesive nanofibers for treatment of oral lichen planus.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Hybrid Nanofibers for Multimodal Accelerated Wound Healing.Advanced healthcare materials · 2026Article
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- Fermented Plant Extract-Loaded Collagen Scaffolds: Bioactive Hydrogels for Enhanced Wound Repair and Immune Modulation.Gels (Basel, Switzerland) · 2026Article
- Review
- A comparison of electrospinning and pressurized gyration: Production of empagliflozin-loaded polylactic acid/polycaprolactone fibrous patches.Journal of the Royal Society, Interface · 2025Article
- Improvement in the Sustained-Release Performance of Electrospun Zein Nanofibers via Crosslinking Using Glutaraldehyde Vapors.Foods (Basel, Switzerland) · 2024Article
- Psidium guajava L. phenolic compound-reinforced lamellar scaffold for tracheal tissue engineering.Drug delivery and translational research · 2024Article
- Role of Polymer Concentration on the Release Rates of Proteins from Single- and Double-Network Hydrogels.International journal of molecular sciences · 2023Article
- Hyaluronic Acid-Based Nanosystems for CD44 Mediated Anti-Inflammatory and Antinociceptive Activity.International journal of molecular sciences · 2023Review
- Progress of Polysaccharide-Contained Polyurethanes for Biomedical Applications.Tissue engineering and regenerative medicine · 2022Review
- Article
- Electrospun Core-Sheath Nanofibers with Variable Shell Thickness for Modifying Curcumin Release to Achieve a Better Antibacterial Performance.Biomolecules · 2022Article
- Elaborate design of shell component for manipulating the sustained release behavior from core-shell nanofibres.Journal of nanobiotechnology · 2022Article
- Dexamethasone-Loaded Ureasil Hydrophobic Membrane for Bone Guided Regeneration.Pharmaceutics · 2022Article
- Stimuli-Responsive Nanofibers Containing Gold Nanorods for On-Demand Drug Delivery Platforms.Pharmaceutics · 2021Article
- Uric acid released from poly(ε-caprolactone) fibers as a treatment platform for spinal cord injury.Journal of tissue engineering and regenerative medicine · 2021Article
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- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is known that the behavior of a drug released from a supporting carrier is influenced by the surrounding environment and the carrier. In this study, we investigated the drug behavior of a swellable electrospun nanofibrous membrane. Nanofibrous mats with different swelling ratios were prepared by mixing cellulose acetate (CA) and polyurethane (PU). CA has excellent biocompatibility and is capable of high water uptake, while PU has excellent mechanical properties. Paclitaxel (PTX) was the drug of choice for observing drug release behavior, which was characterized by UV-spectroscopy. FE-SEM was used to confirm the morphology of the nanofibrous mats and to measure the average fiber diameters. We observed a noticeable increase in the total volume of the nanofibrous membrane when it was immersed in water. Also, the drug release behavior increased proportionally with increasing swelling rate of the composite nanofibrous mat. Biocompatibility testing of nanofiber materials was confirmed by CCK-8 assay and cell morphology was observed. Based on these results, we propose nanofibrous mats as promising candidates in wound dressing and other drug carrier applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.