Evidence map›Paper›PMID 31438467›Full record

ArticleInternational journal of molecular sciences2019

CRB2 Loss in Rod Photoreceptors Is Associated with Progressive Loss of Retinal Contrast Sensitivity.

C Henrique Alves, Nanda Boon, Aat A Mulder, Abraham J Koster, Carolina R Jost, Jan Wijnholds

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Diverse functions and pathogenetic role of Crumbs in retinopathy.Cell communication and signaling : CCS · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. World journal of clinical cases · 2021
    Article
  9. AAV-Molecular therapy. Methods & clinical development · 2021
    Article
  10. Article
  11. Research Models and Gene Augmentation Therapy forFrontiers in neuroscience · 2020
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

C Henrique AlvesDepartment of Ophthalmology, Leiden University Medical Center (LUMC), Albinusdreef 2, 2333 ZA Leiden, The Netherlands.ORCID 0000-0001-9776-5701
Nanda BoonDepartment of Ophthalmology, Leiden University Medical Center (LUMC), Albinusdreef 2, 2333 ZA Leiden, The Netherlands.ORCID 0000-0001-9756-8898
Aat A MulderDepartment of Cell & Chemical Biology, Leiden University Medical Center (LUMC), 2300 RC Leiden, The Netherlands.ORCID 0000-0002-4779-099X
Abraham J KosterDepartment of Cell & Chemical Biology, Leiden University Medical Center (LUMC), 2300 RC Leiden, The Netherlands.
Carolina R JostDepartment of Cell & Chemical Biology, Leiden University Medical Center (LUMC), 2300 RC Leiden, The Netherlands.ORCID 0000-0001-8342-1094
Jan WijnholdsDepartment of Ophthalmology, Leiden University Medical Center (LUMC), Albinusdreef 2, 2333 ZA Leiden, The Netherlands. j.wijnholds@lumc.nl.ORCID 0000-0003-0099-460X
Leiden University Medical Center · NLNetherlands Institute for Neuroscience · NL

Funding

Foundation Fighting Blindness TA-GT-0715-0665-LUMCLeiden Regenerative Medicine Platform 2018-Project-BRotterdamse Stichting Blindenbelangen and Landelijke Stichting voor Blinden en Slechtzienden Uitzicht-2018-6ZonMw 43200004
6 · The paper itself

Abstract

Variations in the Crumbs homolog-1 (

Indexed as

AnimalsContrast SensitivityDisease Models, AnimalElectroretinographyImmunohistochemistryLeber Congenital AmaurosisMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMicroscopy, Electron, TransmissionRetinaRetinal DegenerationRetinal Rod Photoreceptor CellsRetinitis PigmentosaCrb2 protein, mouseMembrane Proteinscrumbs complexcrumbs homolog-1Leber congenital amaurosisphotoreceptorsretinaretinal degenerationretinitis pigmentosarod photoreceptors

Identifiers

PMID31438467
PMCPMC6747345
OpenAlexW2969494333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.