ArticleNeuroImage. Clinical2019
Expansion of hippocampal and amygdala shape in posttraumatic stress and early life stress.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Impact of Post-Traumatic Stress Disorder Duration on Volumetric and Microstructural Parameters of the Hippo-Campus, Amygdala, and Prefrontal Cortex: A Multiparametric Magnetic Resonance Imaging Study with Correlation Analysis.Journal of clinical medicine · 2025Article
- Childhood abuse and neglect are differentially related to perceived discrimination and structural change in empathy-related circuitry.Scientific reports · 2025Article
- Electroretinographic dysfunction, insulin resistance, and childhood trauma in early-course psychosis: A case-control exploratory study.Biomarkers in neuropsychiatry · 2024Article
- Long-term effects of childhood trauma subtypes on adult brain function.Brain and behavior · 2023Article
- Experience-dependent associations between distinct subtypes of childhood trauma and brain function and architecture.Quantitative imaging in medicine and surgery · 2022Article
- Elastic shape analysis of brain structures for predictive modeling of PTSD.Frontiers in neuroscience · 2022Article
- Association between abnormal plasma metabolism and brain atrophy in alcohol-dependent patients.Frontiers in molecular neuroscience · 2022Article
- Neural response to trauma-related and trauma-unrelated negative stimuli in remitted and persistent pediatric post-traumatic stress disorder.Brain and behavior · 2021Article
- Amygdala size varies with stress perception.Neurobiology of stress · 2021Article
- Default Mode Network Alterations Induced by Childhood Trauma Correlate With Emotional Function and SLC6A4 Expression.Frontiers in psychiatry · 2021Article
- Effects of childhood trauma experience and COMT Val158Met polymorphism on brain connectivity in a multimodal MRI study.Brain and behavior · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveThe aim of this study was to examine the effect of Posttraumatic Stress Disorder (PTSD) and childhood adversity on brain structure. We assessed hippocampal and amygdala shape in veterans with varying levels of PTSD symptom severity and exposure to early life stressors (ELS).
methodsA total of 70 male veterans, who were deployed to a combat area during OIF/OEF/OND and who had been exposed to trauma during deployment, were included in the study. We applied a vertex-wise shape analysis of 3T MRI scans to measure indentation or expansion in hippocampal and amygdala shape.
resultsAnalyses showed a positive correlation between number of ELS and vertices in the right amygdala and the right hippocampus, as well as a positive correlation between PTSD symptom severity and right hippocampal vertices. There were no significant interactions between PTSD symptoms, ELS, and brain shape. DISCUSSION: Results indicate a relationship between exposure to more childhood adversity and expansion in amygdala and hippocampal shape as well as between more severe PTSD symptoms and expansion in hippocampal shape. These findings may have important implications for the pathophysiology of trauma-related disorders.
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