ArticleNeurobiology of aging2019
Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults.
Article in Neurobiology of aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Medial temporal lobe atrophy is associated with age and pathologies, especially small vessel disease.Scientific reports · 2026Article
- Integrating MRI Volume and Plasma p-Tau217 for Amyloid Risk Stratification in Early-Stage Alzheimer Disease.Neurology · 2025Article
- Abnormal Amyloid-β Duration, Tau, and Neurodegeneration in Cranial Images.JAMA network open · 2025Article
- Preserved brain youthfulness: longitudinal evidence of slower brain aging in superagers.GeroScience · 2025Article
- Cross-sectional and longitudinal relationships among blood-brain barrier disruption, Alzheimer's disease biomarkers, and cognition in cognitively normal older adults.Neurobiology of aging · 2025Article
- The Association between the rs6656401 Locus of the CR1 Gene and Structural Alterations of Brain Effects in Han Chinese Patients with Alzheimer's Disease.Current Alzheimer research · 2025Article
- Brain MRI signatures across sex and CSF Alzheimer's disease biomarkers.Brain communications · 2025Article
- Intrinsic functional and structural network organization in the macaque insula.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- The characteristics of brain atrophy prior to the onset of Alzheimer's disease: a longitudinal study.Frontiers in aging neuroscience · 2024Article
- Lateral Entorhinal Cortex Suppresses Drift in Cortical Memory Representations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Associations Between Sub-Threshold Amyloid-β Deposition, Cortical Volume, and Cognitive Function Modulated by APOE ɛ4 Carrier Status in Cognitively Normal Older Adults.Journal of Alzheimer's disease : JAD · 2022Article
- Neuronal Code for Episodic Time in the Lateral Entorhinal Cortex.Frontiers in integrative neuroscience · 2022Article
- Predicting amyloid status using self-report information from an online research and recruitment registry: The Brain Health Registry.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Atrophy of specific amygdala subfields in subjects converting to mild cognitive impairment.Alzheimer's & dementia (New York, N. Y.)Article
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Authors and funding
10 authors.
Funding
Abstract
The goal of this study was to compare regional brain atrophy patterns in cognitively unimpaired (CU) older adults with and without brain accumulation of amyloid-β (Aβ) to elucidate contributions of Aβ, age, and other variables to atrophy rates. In 80 CU participants from the Alzheimer's Disease Neuroimaging Initiative, we determined effects of Aβ and age on longitudinal, regional atrophy rates, while accounting for confounding variables including sex, APOE ε4 genotype, white matter lesions, and cerebrospinal fluid total and phosphorylated tau levels. We not only found overlapping patterns of atrophy in Aβ+ versus Aβ- participants but also identified regions where atrophy pattern differed between the 2 groups. Higher Aβ load was associated with increased longitudinal atrophy in the entorhinal cortex, amygdala, and hippocampus, even when accounting for age and other variables. Age was associated with atrophy in insula, fusiform gyrus, and isthmus cingulate, even when accounting for Aβ. We found age by Aβ interactions in the postcentral gyrus and lateral orbitofrontal cortex. These results elucidate the separate and related effects of age, Aβ, and other important variables on longitudinal brain atrophy rates in CU older adults.
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