ArticleACS combinatorial science2019
One-Pot Parallel Synthesis of 5-(Dialkylamino)tetrazoles.
Article in ACS combinatorial science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- AI-enhanced adaptive virtual screening of large libraries for ligand discovery.Nature biotechnology · 2026Article
- AI-Enhanced Adaptive Virtual Screening Platform Enabling Exploration of 69 Billion Molecules Discovers Structurally Validated FSP1 Inhibitors.bioRxiv : the preprint server for biology · 2026Article
- Synthesis of triazolo- and tetrazolo-fused 1,4-benzodiazepines via one-pot Ugi-azide and Cu-free click reactions.Beilstein journal of organic chemistry · 2025Article
- Generation of multimillion chemical space based on the parallel Groebke-Blackburn-Bienaymé reaction.Beilstein journal of organic chemistry · 2024Article
- Nanomagnetic tetraaza (NNanoscale advances · 2023Article
- Creation of targeted compound libraries based on 3D shape recognition.Molecular diversity · 2023Article
- Article
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Authors and funding
13 authors.
Funding
Abstract
Two protocols for the combinatorial synthesis of 5-(dialkylamino)tetrazoles were developed. The best success rate (67%) was shown by the method that used primary and secondary amines, 2,2,2-trifluoroethylthiocarbamate, and sodium azide as the starting reagents. The key steps included the formation of unsymmetrical thiourea, subsequent alkylation with 1,3-propane sultone and cyclization with azide anion. A 559-member aminotetrazole library was synthesized by this approach; the overall readily accessible (REAL) chemical space covered by the method exceeded 7 million feasible compounds.
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Registered trials
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