Evidence map›Paper›PMID 31437392›Full record

ArticleJournal of medicinal chemistry2019

Structure Kinetics Relationships and Molecular Dynamics Show Crucial Role for Heterocycle Leaving Group in Irreversible Diacylglycerol Lipase Inhibitors.

Antonius P A Janssen, Jacob M A van Hengst, Olivier J M Béquignon, Hui Deng, Gerard J P van Westen, Mario van der Stelt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Enhancing Selectivity and Potency of SJournal of medicinal chemistry · 2025
    Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Antonius P A JanssenMolecular Physiology, Leiden Institute of Chemistry , Leiden University , 2300RA Leiden , The Netherlands.ORCID 0000-0003-4203-261X
Jacob M A van HengstMolecular Physiology, Leiden Institute of Chemistry , Leiden University , 2300RA Leiden , The Netherlands.
Olivier J M BéquignonDivision of Drug Discovery and Safety, Leiden Academic Centre for Drug Research , Leiden University , P.O. Box 9502, 2300 RA Leiden , The Netherlands.
Hui DengMolecular Physiology, Leiden Institute of Chemistry , Leiden University , 2300RA Leiden , The Netherlands.ORCID 0000-0003-0899-4188
Gerard J P van WestenDivision of Drug Discovery and Safety, Leiden Academic Centre for Drug Research , Leiden University , P.O. Box 9502, 2300 RA Leiden , The Netherlands.
Mario van der SteltMolecular Physiology, Leiden Institute of Chemistry , Leiden University , 2300RA Leiden , The Netherlands.ORCID 0000-0002-1029-5717

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug discovery programs of covalent irreversible, mechanism-based enzyme inhibitors often focus on optimization of potency as determined by IC

Indexed as

Molecular Dynamics SimulationDose-Response Relationship, DrugEnzyme InhibitorsHeterocyclic CompoundsHumansKineticsLipoprotein LipaseMolecular StructureStructure-Activity RelationshipEnzyme InhibitorsHeterocyclic CompoundsLipoprotein LipaseLPL protein, human

Identifiers

PMID31437392
PMCPMC6745892

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.