Evidence map›Paper›PMID 31437326›Full record

ArticleNMR in biomedicine2019

Hyperpolarized

Lydia M Le Page, Caroline Guglielmetti, Chloé F Najac, Brice Tiret, Myriam M Chaumeil

Open access · bronzeAbstract read
In one paragraph

Article in NMR in biomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Investigating the origin of theNMR in biomedicine · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. Probing Cerebral Metabolism with HyperpolarizedACS chemical neuroscience · 2021
    Article
  8. Article
  9. Review
  10. HyperpolarizedNMR in biomedicine · 2021
    Review
  11. HyperpolarizedBiomedicines · 2021
    Article
  12. Review
  13. Imaging Brain Metabolism Using HyperpolarizedTrends in neurosciences · 2020
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Lydia M Le PageDepartment of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, California.ORCID 0000-0002-3807-4772
Caroline GuglielmettiDepartment of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, California.
Chloé F NajacDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Brice TiretDepartment of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, California.
Myriam M ChaumeilDepartment of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, California.
University of California, San Francisco · USLeiden University Medical Center · NL

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Daniel B Vigneron · 2011 to 2026
$19.9M
MR Metabolic Imaging of Multiple SclerosisR01NS102156 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jeremy William Gordon, Ari J Green · 2017 to 2026
$3.4M
NIBIB NIH HHS P41 EB013598NINDS NIH HHS R01 NS102156
6 · The paper itself

Abstract

Lipopolysaccharide (LPS) is a commonly used agent for induction of neuroinflammation in preclinical studies. Upon injection, LPS causes activation of microglia and astrocytes, whose metabolism alters to favor glycolysis. Assessing in vivo neuroinflammation and its modulation following therapy remains challenging, and new noninvasive methods allowing for longitudinal monitoring would be highly valuable. Hyperpolarized (HP)

Indexed as

Carbon-13 Magnetic Resonance SpectroscopyAnimalsBrainInflammationLactic AcidLipopolysaccharidesMaleMice, Inbred C57BLNerve Tissue ProteinsNeurotoxinsPyruvic AcidLactic AcidLipopolysaccharidesNerve Tissue ProteinsNeurotoxinsPyruvic Acidhyperpolarized 13C MRSlipopolysaccharidemetabolismneuroinflammation

Identifiers

PMID31437326
PMCPMC6817388
OpenAlexW2969255060

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.