Trial reportPloS one2019
How well do postpartum blood loss and common definitions of postpartum hemorrhage correlate with postpartum anemia and fall in hemoglobin?
Trial report in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05525143 (Incidence and Risk Factors of Postpartum Hemorrhage at the Brugmann University Hospital in Comparison to the Literature), which is not on this map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Incidence and Risk Factors of Postpartum Hemorrhage at the Brugmann University Hospital in Comparison to the Literature
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- FIGO good practice recommendations on anemia in pregnancy, to reduce the incidence and impact of postpartum hemorrhage (PPH).International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Guideline
- Tests for diagnosis of postpartum haemorrhage at vaginal birth.The Cochrane database of systematic reviews · 2025Pooled it
- Analysis of the efficacy of prophylactic tranexamic acid in preventing postpartum bleeding: systematic review with meta-analysis of randomized clinical trials.Brazilian journal of anesthesiology (Elsevier)Pooled it
- Accurate estimation of blood loss during cesarean deliveries: A secondary analysis of a randomized controlled trial comparing visual, quantitative and calculated approaches.Acta obstetricia et gynecologica Scandinavica · 2025Trial
- Screening performance of quantitative blood loss for postpartum anemia among patients without baseline anemia.AJOG global reports · 2026Article
- Prevalence, characteristics, and outcomes of postpartum hemorrhage in a tertiary hospital in Tigray, Northern Ethiopia (2017-2021): retrospective descriptive study.BMC pregnancy and childbirth · 2026Article
- Postpartum well-being in hemophilia carriers and women with von Willebrand disease: insights from patient-reported outcome measures.Research and practice in thrombosis and haemostasis · 2026Article
- Tranexamic acid in the management of postpartum hemorrhage following vacuum-assisted vaginal delivery in primiparous women: a retrospective cohort study.BMC pregnancy and childbirth · 2025Article
- Quantitative Validation of Hematocrit Percentage Drop Cutoff Points in Postpartum Hemorrhage: An Automated Gravimetric Approach.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2025Article
- Seasonal Factors Associated with Surgical Site Infections Following Gynecologic and Obstetric Surgeries and Pathogen Identification: A Retrospective Study in A Single Center in China.Risk management and healthcare policy · 2025Article
- Uterine Reaction to Oxytocin and Maternal-Neonatal Outcomes in Inducing Labor: A Retrospective Cohort Study.International journal of women's health · 2025Article
- Predicting Intra- and Postpartum Hemorrhage through Artificial Intelligence.Medicina (Kaunas, Lithuania) · 2024Article
- Do Patients with Borderline Anemia Need Treatment before Total Hip Arthroplasty? A Propensity Score-Matched Cohort Study.Orthopaedic surgery · 2024Article
- Clinical value of ultrasonic indicators in predicting the outcome of caesarean scar pregnancy after pregnancy termination.BMC pregnancy and childbirth · 2023Article
- Biology of Anemia: A Public Health Perspective.The Journal of nutrition · 2023Article
- Accelerating action to reduce anemia: Review of causes and risk factors and related data needs.Annals of the New York Academy of Sciences · 2023Review
- Change in Hemoglobin Was Not a Reliable Diagnostic Screening Test for Postpartum Hemorrhage: A French Prospective Multicenter Cohort Study (HERA Study).Healthcare (Basel, Switzerland) · 2023Article
- Biological response of nonhuman primates to controlled levels of acute blood loss.Frontiers in immunology · 2023Article
- Barriers to effective management of primary postpartum haemorrhage following in-hospital births in northwest Ethiopia: healthcare providers' views using a qualitative approach.BMC pregnancy and childbirth · 2022Article
- Effect of personalized home-based support for pregnant women on pregnancy outcomes: a cluster randomized trial.Journal of public health in Africa · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to better understand how well postpartum blood loss and common postpartum hemorrhage (PPH) definitions (i.e. blood loss ≥500ml = PPH, ≥1000ml = "severe" PPH) correlate with postpartum anemia and fall in hemoglobin.
methodsSecondary analysis of data from three randomized trials that objectively measured postpartum blood loss and pre- and post-delivery hemoglobin among vaginal deliveries: one trial included 1056 home-births in Pakistan and two multi-country hospital-based trials included 1279 women diagnosed with PPH. We calculated Spearman's correlation coefficients (rs) for blood loss with hemoglobin drop and postpartum hemoglobin, and we compared PPH blood loss markers (≥500ml, ≥1000ml) with large hemoglobin drops (≥2 g/dL) and the threshold for moderate postpartum anemia (<10g/dL).
resultsIn the Pakistan study and the multi-country trials, blood loss was weakly correlated with hemoglobin drop (Pakistan: rs = -0.220, multi-country trials: rs = -0.271) and postpartum hemoglobin (Pakistan: rs = -0.220, multi-country trials: rs = -0.316). In both the Pakistan and multi-country trials, hemoglobin drop ≥2 g/dL occurred in less than half of women with 500-999 ml blood loss (55/175 [31%] and 302/725 [42%], respectively) and was more common among women who bled ≥1000ml (19/28 [68%] and 347/554 [63%], respectively). Similarly, in the Pakistan and multi-country trials, postpartum anemia <10 g/dL was less frequent among women who bled 500-999 ml (55/175 [31%] and 390/725 [54%], respectively) and more frequent among women with ≥1000ml blood loss (20/28 [71%] and 416/554 [75%], respectively).
conclusionsPostpartum morbidity as measured by hemoglobin markers was common for women with blood loss ≥1000ml and relatively infrequent among women with blood loss 500-999ml. These findings reinforce the importance of severe PPH as the preferred outcome to be used in research. The weak correlation between blood loss and hemoglobin markers also suggests that this relationship is not straightforward and should be carefully interpreted.
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