ArticleBrain : a journal of neurology2019
Burst suppression uncovers rapid widespread alterations in network excitability caused by an acute seizure focus.
Article in Brain : a journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 17 citations in OpenAlex.
- Cell-type-specific networks during hippocampal seizures at the micro- and macroscale.Brain : a journal of neurology · 2025Article
- Inhibiting astrocyte calcium dynamics terminates status epilepticus via wireless septal stimulation.Scientific reports · 2025Article
- Gabrb3 is required for the functional integration of pyramidal neuron subtypes in the somatosensory cortex.Neuron · 2023Article
- Human interictal epileptiform discharges are bidirectional traveling waves echoing ictal discharges.eLife · 2022Article
- Article
- Isoflurane-Induced Burst Suppression Is a Thalamus-Modulated, Focal-Onset Rhythm With Persistent Local Asynchrony and Variable Propagation Patterns in Rats.Frontiers in systems neuroscience · 2020Article
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Authors and funding
7 authors at 3 institutions in 1 country.
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Abstract
Burst suppression is an electroencephalogram pattern of globally symmetric alternating high amplitude activity and isoelectricity that can be induced by general anaesthetics. There is scattered evidence that burst suppression may become spatially non-uniform in the setting of underlying pathology. Here, we induced burst suppression with isoflurane in rodents and then created a neocortical acute seizure focus with injection of 4-aminopyridine (4-AP) in somatosensory cortex. Burst suppression events were recorded before and after creation of the focus using bihemispheric wide-field calcium imaging and multielectrode arrays. We find that the seizure focus elicits a rapid alteration in triggering, initiation, and propagation of burst suppression events. Compared with the non-seizing brain, bursts are triggered from the thalamus, initiate in regions uniquely outside the epileptic focus, elicit marked increases of multiunit activity and propagate towards the seizure focus. These findings support the rapid, widespread impact of focal epilepsy on the extended brain network.
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