ReviewEuropean journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)2020
Phytol and its metabolites phytanic and pristanic acids for risk of cancer: current evidence and future directions.
Review in European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Phytol in Skin Care: From Multidimensional Pharmacological Mechanisms to Nanocarrier-Based Cosmetic Applications.International journal of molecular sciences · 2026Review
- Targeting cancer and SARS-CoV-2: phytochemical, biological and molecular dynamic investigations of Sargassum aquifolium and Galaxaura rugosa.Scientific reports · 2025Article
- Phytochemical based on nanoparticles for neurodegenerative alzheimer disease management: Update review.Discover nano · 2025Review
- Phytyl Phenolipids: Structurally Modified Antioxidants with Superior Lipid Membrane Interaction.Molecules (Basel, Switzerland) · 2025Article
- Phytochemical Characterization and Antioxidant Activity ofMolecules (Basel, Switzerland) · 2025Article
- Article
- New Phytol Derivatives with Increased Cosmeceutical Potential.Molecules (Basel, Switzerland) · 2024Article
- The Modulatory Effect of an Ethanolic Extract ofOxidative medicine and cellular longevity · 2024Article
- Dairy product consumption and lung cancer risk: A prospective analysis.Clinical nutrition ESPEN · 2023Article
- Preliminary observational study of metabonomics in patients with early and late-onset type 2 diabetes mellitus based on UPLC-Q-TOF/MS.Scientific reports · 2023Observational
- Phytochemical profile and biological activities of the essential oils in the aerial part and root of Saposhnikovia divaricata.Scientific reports · 2023Article
- Article
- Natural Inhibitors of P-glycoprotein in Acute Myeloid Leukemia.International journal of molecular sciences · 2023Review
- Microbial Metabolites as Ligands to Xenobiotic Receptors: Chemical Mimicry as Potential Drugs of the Future.Drug metabolism and disposition: the biological fate of chemicals · 2023Review
- Phytanic acid, an inconclusive phytol metabolite: A review.Current research in toxicology · 2023Article
- Acyclic Diterpene Phytol from Hemp Seed Oil (Foods (Basel, Switzerland) · 2022Article
- Natural Product-based Nanomedicine: Recent Advances and Issues for the Treatment of Alzheimer's Disease.Current neuropharmacology · 2022Article
- Dynamics and correlations of chlorophyll and phytol content with silage bacterial of different growth heightsFrontiers in plant science · 2022Article
- Novel Rotational Combination Regimen of Skin Topicals Improves Facial Photoaging: Efficacy Demonstrated in Double-Blinded Clinical Trials and Laboratory Validation.Frontiers in medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review summarizes the current evidence on the potential role of phytol, a microbial metabolite of chlorophyl A, and its metabolites, phytanic and pristanic acids, in carcinogenesis. Primary food sources in Western diets are the nut skin for phytol and lipids in dairy, beef and fish for its metabolites. Phytol and its metabolites gained interest as dietary compounds for cancer prevention because, as natural ligands of peroxisome proliferator-activated receptor-α and -γ and retinoid X receptor, phytol and its metabolites have provided some evidence in cell culture studies and limited evidence in animal models of anti-carcinogenic, anti-inflammatory and anti-metabolic-syndrome properties at physiological concentrations. However, there may be a narrow range of efficacy, because phytol and its metabolites at supra-physiological concentrations can cause in vitro cytotoxicity in non-cancer cells and can cause morbidity and mortality in animal models. In human studies, evidence for a role of phytol and its metabolites in cancer prevention is currently limited and inconclusive. In short, phytol and its metabolites are potential dietary compounds for cancer prevention, assuming the challenges in preventing cytotoxicity in non-cancer cells and animal models and understanding phytol metabolism can be mitigated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.