Evidence map›Paper›PMID 31436344›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2020

In Vitro Evidence for Cell-Accelerated Corrosion Within Modular Junctions of Total Hip Replacements.

Divya Rani Bijukumar, Shruti Salunkhe, Dalton Morris, Abhijith Segu, Deborah J Hall, Robin Pourzal, Mathew T Mathew

Abstract read
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Metal Fatigue Fracture After Revision Total Knee Arthroplasty: A Retrieval Analysis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Do total shoulder arthroplasty implants corrode?Journal of shoulder and elbow surgery · 2022
    Article
  7. Article
  8. In vitro testing for hip head-neck taper tribocorrosion: A review of experimental methods.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2022
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Divya Rani BijukumarDepartment of Biomedical Sciences, University of Illinois College of Medicine at Rockford, 1601 Parkview Ave, Rockford, IL, 61107.ORCID 0000-0001-8114-5444
Shruti SalunkheDepartment of Biomedical Sciences, University of Illinois College of Medicine at Rockford, 1601 Parkview Ave, Rockford, IL, 61107.
Dalton MorrisDepartment of Biomedical Sciences, University of Illinois College of Medicine at Rockford, 1601 Parkview Ave, Rockford, IL, 61107.
Abhijith SeguDepartment of Biomedical Sciences, University of Illinois College of Medicine at Rockford, 1601 Parkview Ave, Rockford, IL, 61107.
Deborah J HallDepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois.
Robin PourzalDepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois.
Mathew T MathewDepartment of Biomedical Sciences, University of Illinois College of Medicine at Rockford, 1601 Parkview Ave, Rockford, IL, 61107.

Funding

Corrosion Induced Hip Implant Failure: Synergistic Interactions of Patient, Material, Design, and Surgical FactorsR01AR070181 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI LUNDBERG, HANNAH JEAN, MATHEW, MATHEW THOPPIL · 2016 to 2020
$2.3M
NIAMS NIH HHS R01 AR070181NIH HHS NIH R01 AR070181
6 · The paper itself

Abstract

Corrosion at modular junctions of total hip replacement (THR) remains a major concern today. Multiple types of damage modes have been identified at modular junctions, correlated with different corrosion characteristics that may eventually lead to implant failure. Recently, within the head-taper region of the CoCrMo retrieval implants, cell-like features and trails of etching patterns were observed that could potentially be linked to the involvement of cells of the periprosthetic region. However, there is no experimental evidence to corroborate this phenomenon. Therefore, we aimed to study the potential role of periprosthetic cell types on corrosion of CoCrMo alloy under different culture conditions, including the presence of CoCrMo wear debris. Cells were incubated with and without CoCrMo wear debris (obtained from a hip simulator) with an average particle size of 119 ± 138 nm. Electrochemical impedance spectroscopy (EIS) was used to evaluate the corrosion tendency, corrosion rate, and corrosion kinetics using the media after 24 h of cell culture as the electrolyte. Results of the study showed that there was lower corrosion resistance (p < 0.02) and higher capacitance (p < 0.05) within cell media from macrophages challenged with particles when compared with the other media conditions studied. The potentiodynamic results were also in agreement with the EIS values, showing significantly higher corrosion tendency (low E

Indexed as

Arthroplasty, Replacement, HipCell LineCorrosionElectrochemical TechniquesHip ProsthesisHumansMacrophagesToxicity TestsCoCrMocorrosionelectrochemical impedance spectroscopy (EIS)macrophagesTotal Hip Replacements (THR)

Identifiers

PMID31436344
PMCPMC7370985

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.