Evidence map›Paper›PMID 31436333›Full record

ArticleClinical cardiology2019

Use of Impella heart pump for management of women with peripartum cardiogenic shock.

Uri Elkayam, Andreas Schäfer, Alaide Chieffo, Alexandra Lansky, Shelley Hall, Zoltan Arany, Cindy Grines

Open access · goldAbstract read
In one paragraph

Article in Clinical cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. What Do We Know about Peripartum Cardiomyopathy? Yesterday, Today, Tomorrow.International journal of molecular sciences · 2024
    Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Peripartum Cardiogenic Shock and Mechanical Circulatory Support.Interventional cardiology (London, England) · 2023
    Review
  16. Review
  17. Article
  18. Acute Coronary Syndrome in Pregnancy and the Post-Partum Period.Journal of cardiovascular development and disease · 2022
    Review
  19. Article
  20. Peripartum cardiomyopathy: a review.Heart failure reviews · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 3 countries.

Uri ElkayamUniversity of Southern California, Los Angeles, California.ORCID https://orcid.org/0000-0003-3150-5709
Andreas SchäferHannover Medical School, Hannover, Germany.
Alaide ChieffoSan Raffaele Scientific Institute, Milan, Italy.
Alexandra LanskyYale School of Medicine, New Haven, Connecticut.
Shelley HallBaylor University Medical Center, Dallas, Texas.
Zoltan AranyUniversity of Pennsylvania, Philadelphia, Pennsylvania.
Cindy GrinesNorthwell Health, Manhasset, New York.
Baylor University Medical Center · USMedizinische Hochschule Hannover · DENorthwell Health · USSan Raffaele University of Rome · ITUniversity of Pennsylvania · USUniversity of Southern California · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
AbiomedNCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

backgroundPercutaneous mechanical circulatory support (MCS), such as the Impella heart pump is a valuable option for cardiogenic shock (CS), although the use of Impella in CS due to peripartum cardiomyopathy (PPCM) is limited.

objectiveTo assess outcomes in women with PPCM supported with an Impella device from the global catheter-based ventricular assist device (cVAD) Registry. METHODS AND

resultsA total of 15 women with PPCM supported with Impella devices between November 2008 and October 2015 were included. Of the 15 women, five were treated at Hannover medical school and have been reported previously, the rest were managed at various US hospitals. The mean age was 30.0 ± 7.34 years, eight women were Caucasian, and seven were African-American. The occurrence of PPCM was post-delivery in eight (53.3%), at delivery in one (6.7%), and during gestation in four women (26.7%). At admission, all women had severe heart failure with a mean ejection fraction of 14.7 ± 6% and 13 women (86.7%) presented with CS. Prior to Impella, 100% were mechanically ventilated, 79% received inotropes/vasopressors, 20% supported with IABP, and 27% received veno-arterial extracorporeal membrane oxygenation (VA ECMO) during Impella support. Two women (13.3%) died, and 13 (87.7%) survived to discharge. Eight women (53.3%) had a recovery of native heart function and six (40%) were bridged to durable left ventricular assist device (LVAD).

conclusionMCS with Impella devices can be successfully used as a bridge to early improvement, heart recovery, or successful implantation of durable LVAD in women with PPCM complicated by severe LV dysfunction.

Indexed as

Heart-Assist DevicesPeripartum PeriodPregnancy Complications, CardiovascularRegistriesAdultCardiomyopathiesFemaleFollow-Up StudiesHumansPregnancyRetrospective StudiesShock, CardiogenicTime FactorsTreatment OutcomeVentricular Dysfunction, Leftheart failureImpella heart pumpsmechanical circulatory supportperipartum cardiomyopathy

Identifiers

PMID31436333
PMCPMC6788473
OpenAlexW2969883969

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.