Evidence map›Paper›PMID 31436070›Full record

ArticleJournal of biomedical optics2019

Handheld projective imaging device for near-infrared fluorescence imaging and intraoperative guidance of sentinel lymph node resection.

Chenmeng Li, Peng Liu, Pengfei Shao, Jing Pei, Yingrui Li, Timothy M Pawlik, Edward W Martin, Ronald X Xu

Open access · goldAbstract read
In one paragraph

Article in Journal of biomedical optics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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  9. Real-TimeFrontiers in oncology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Chenmeng LiUniversity of Science and Technology of China, Department of Precision Machinery and Precision Instr, China.
Peng LiuUniversity of Science and Technology of China, Department of Precision Machinery and Precision Instr, China.
Pengfei ShaoUniversity of Science and Technology of China, Department of Precision Machinery and Precision Instr, China.
Jing PeiFirst Affiliated Hospital of Anhui Medical University, Department of General Surgery, Hefei, Anhui, China.
Yingrui LiUniversity of Science and Technology of China, Department of Precision Machinery and Precision Instr, China.
Timothy M PawlikOhio State University, Department of Surgery, Columbus, Ohio, United States.
Edward W MartinOhio State University, Department of Surgery, Columbus, Ohio, United States.
Ronald X XuUniversity of Science and Technology of China, Department of Precision Machinery and Precision Instr, China.
University of Science and Technology of China · CNThe Ohio State University · USFirst Affiliated Hospital of Anhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We propose a handheld projective imaging device for orthotopic projection of near-infrared fluorescence images onto target biological tissue at visible wavelengths without any additional visual aid. The device integrates a laser diode light source module, a camera module, a projector, an ultrasonic distance sensor, a Raspberry Pi single-board computer, and a battery module in a rugged handheld unit. It is calibrated at the detected working distance for seamless coregistration between fluorescence emission and projective imaging at the target tissue site. The proposed device is able to achieve a projection resolution higher than 314  μm and a planar projection bias less than 1 mm at a projection field of view of 58  ×  108  mm2 and a working distance of 27 cm. Technical feasibility for projective imaging is verified in an ex vivo model of chicken breast tissue using indocyanine green as a fluorescence agent. Clinical utility for image-guided surgery is demonstrated in a clinical trial where sentinel lymph nodes in breast cancer patients are identified and resected under the guidance of projective imaging. Our ex vivo and in vivo experiments imply the clinical utility of deploying the proposed device for image-guided surgical interventions in resource-limited settings.

Indexed as

Surgery, Computer-AssistedBreast NeoplasmsEquipment DesignFemaleFluorescenceHumansIndocyanine GreenLasersLymphatic MetastasisOptical ImagingSentinel Lymph NodeSentinel Lymph Node BiopsySpectrometry, FluorescenceSpectroscopy, Near-InfraredIndocyanine Greenhandheldnear-infrared fluorescence imagingprojective imagingsentinel lymph nodesurgical navigation

Identifiers

PMID31436070
PMCPMC6983473
OpenAlexW2969316895

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.