Evidence map›Paper›PMID 31436047›Full record

ArticleJournal of cachexia, sarcopenia and muscle2019

Associations of fat-soluble micronutrients and redox biomarkers with frailty status in the FRAILOMIC initiative.

Bastian Kochlik, Wolfgang Stuetz, Karine Pérès, Sophie Pilleron, Catherine Féart, Francisco José García García, Stefania Bandinelli, David Gomez-Cabrero, Leocadio Rodriguez-Mañas, Tilman Grune and 1 more

Abstract read
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  4. [Micronutrients in old age-physiological specificities and nutritional status].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bastian KochlikDepartment of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
Wolfgang StuetzDepartment of Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart, Germany.
Karine PérèsInserm, Bordeaux Population Health Research Center, UMR 1219, University Bordeaux, Bordeaux, France.
Sophie PilleronInserm, Bordeaux Population Health Research Center, UMR 1219, University Bordeaux, Bordeaux, France.
Catherine FéartInserm, Bordeaux Population Health Research Center, UMR 1219, University Bordeaux, Bordeaux, France.
Francisco José García GarcíaDivision of Geriatric Medicine, Hospital Virgen del Valle Complejo Hospitalario de Toledo, Toledo, Spain.
Stefania BandinelliGeriatric Unit, Local Health Tuscany Center Agency, Florence, Italy.
David Gomez-CabreroUnit of Computational Medicine, Karolinska Institute, Stockholm, Sweden.
Leocadio Rodriguez-MañasDivision of Geriatrics, Hospital Universitario de Getafe, Getafe, Spain.
Tilman GruneDepartment of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
Daniela WeberDepartment of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.ORCID 0000-0002-2054-6233

Funding

HISPANIC SECONDARY STROKE PREVENTION INITIATIVER01MD009164 · NIMHD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN · 2014 to 2018
$1.9M
NIMHD NIH HHS R01 MD009164
6 · The paper itself

Abstract

backgroundA poor fat-soluble micronutrient (FMN) and a high oxidative stress status are associated with frailty. Our aim was to determine the cross-sectional association of FMNs and oxidative stress biomarkers [protein carbonyls (PrCarb) and 3-nitrotyrosine] with the frailty status in participants older than 65 years.

methodsPlasma levels of vitamins A (retinol), D

resultsRobust participants had significantly higher vitamin D

conclusionsOur study indicates that both low FMN and high PrCarb concentrations are associated with pre-frailty and frailty.

Indexed as

Oxidation-ReductionAgedAged, 80 and overBiomarkersCarotenoidsCross-Sectional StudiesFrailtyHumansLinear ModelsLogistic ModelsMicronutrientsTyrosineVitamin AVitamin E3-nitrotyrosineBiomarkersCarotenoidsMicronutrientsTyrosineVitamin AVitamin E3-NitrotyrosineCarotenoidsFat-soluble micronutrientsFrailProtein carbonyls

Identifiers

PMID31436047
PMCPMC6903435

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.