Evidence map›Paper›PMID 31435890›Full record

ArticleJournal of the American Society for Mass Spectrometry2019

Structural and Energetic Effects of O2'-Ribose Methylation of Protonated Pyrimidine Nucleosides.

C C He, L A Hamlow, Y Zhu, Y-W Nei, L Fan, C P McNary, P Maître, V Steinmetz, B Schindler, I Compagnon and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

C C HeDepartment of Chemistry, Wayne State University, Detroit, MI, 48202, USA.ORCID http://orcid.org/0000-0002-0500-1526
L A HamlowDepartment of Chemistry, Wayne State University, Detroit, MI, 48202, USA.ORCID http://orcid.org/0000-0002-7988-5117
Y ZhuDepartment of Chemistry, Wayne State University, Detroit, MI, 48202, USA.ORCID http://orcid.org/0000-0003-4909-7336
Y-W NeiDepartment of Chemistry, Wayne State University, Detroit, MI, 48202, USA.
L FanDepartment of Chemistry, Wayne State University, Detroit, MI, 48202, USA.
C P McNaryDepartment of Chemistry, University of Utah, Salt Lake City, UT, 84112, USA.
P MaîtreLaboratoire de Chimie Physique (UMR8000), Université Paris-Sud, CNRS, Université Paris Saclay, 91405, Orsay, France.ORCID http://orcid.org/0000-0003-2924-1054
V SteinmetzLaboratoire de Chimie Physique (UMR8000), Université Paris-Sud, CNRS, Université Paris Saclay, 91405, Orsay, France.
B SchindlerUniv Lyon, Université Claude Bernard Lyon 1, CNRS, Institut Lumière Matière, F-69622, Villeurbanne, France.
I CompagnonUniv Lyon, Université Claude Bernard Lyon 1, CNRS, Institut Lumière Matière, F-69622, Villeurbanne, France.ORCID http://orcid.org/0000-0003-2994-3961
P B ArmentroutDepartment of Chemistry, University of Utah, Salt Lake City, UT, 84112, USA.ORCID http://orcid.org/0000-0003-2953-6039
M T RodgersDepartment of Chemistry, Wayne State University, Detroit, MI, 48202, USA. mrodgers@chem.wayne.edu.ORCID http://orcid.org/0000-0002-5614-0948
Wayne State University · USInstitut Lumière Matière · FRUniversity of Utah · USLaboratoire de Chimie Physique · FRUniversité Paris-Saclay · FR

Funding

National Science Foundation CHE-1664618National Science Foundation CHE-1709789National Science Foundation DBI-0922819National Science Foundation OISE-0730072National Science Foundation OISE-1357787
6 · The paper itself

Abstract

The 2'-substituents distinguish DNA from RNA nucleosides. 2'-O-methylation occurs naturally in RNA and plays important roles in biological processes. Such 2'-modifications may alter the hydrogen-bonding interactions of the nucleoside and thus may affect the conformations of the nucleoside in an RNA chain. Structures of the protonated 2'-O-methylated pyrimidine nucleosides were examined by infrared multiple photon dissociation (IRMPD) action spectroscopy, assisted by electronic structure calculations. The glycosidic bond stabilities of the protonated 2'-O-methylated pyrimidine nucleosides, [Nuom+H]

Indexed as

DNA MethylationDNAGasesModels, MolecularProtonsPyrimidine NucleosidesRiboseRNASpectrometry, Mass, Electrospray IonizationDNAGasesProtonsPyrimidine NucleosidesRiboseRNA2′-O-methyl-5-methyluridine (Thdm)2′-O-methylation2′-O-methylcytidine (Cydm)2′-O-methyluridine (Urdm)5-MethyluridineCytidine (Cyd)Cytosine (Cyt)Density functional theory (DFT)Electronic structure calculationsElectrospray ionization (ESI)Energy-resolved collision-induced dissociation (ER-CID)Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS)Gas-phase conformationGlycosidic bond stabilityHydrogen-bonding interactionsHydrogen-stretching regionInfrared multiple photon dissociation (IRMPD) action spectroscopyIR fingerprint regionIRMPD spectrumIR spectrumNucleobaseNucleobase orientationNucleosideNucleoside modificationProtonationPyrimidine nucleosidesQuadrupole ion trap mass spectrometer (QIT MS)Simulated annealingSugar puckeringSurvival yield analysisTandem mass spectrometryThymidine (Thd)Thymine (Thy)Uracil (Ura)Uridine (Urd)

Identifiers

PMID31435890
OpenAlexW2969865701

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.