Evidence map›Paper›PMID 31435862›Full record

ArticleLa Radiologia medica2019

MRI of acute optic neuritis (ON) at the first episode: Can we predict the visual outcome and the development of multiple sclerosis (MS)?

Michaela Cellina, Chiara Floridi, Cristina Rosti, Marcello Orsi, Marta Panzeri, Marta Pirovano, Matteo Ciocca, Giancarlo Oliva, Daniele Gibelli

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Article in La Radiologia medica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Michaela CellinaRadiology Department, ASST Fatebenefratelli Sacco, Piazza Principessa Clotilde 3, 20123, Milan, Italy. michaela.cellina@asst-fbf-sacco.it.ORCID http://orcid.org/0000-0002-7401-1971
Chiara FloridiRadiology Department, San Paolo Hospital, Via A Di Rudinì 8, 20142, Milan, Italy.
Cristina RostiDepartment of Radiology, Civil Hospital, Corso Milano 19, 27029, Vigevano, Italy.
Marcello OrsiRadiology Department, ASST Fatebenefratelli Sacco, Piazza Principessa Clotilde 3, 20123, Milan, Italy.
Marta PanzeriRadiology Department, IRCCS Ospedale San Raffaele, Via Olgettina 23, 20121, Milan, Italy.
Marta PirovanoNeurology Department, ASST Fatebenefratelli Sacco, Piazza Principessa Clotilde 3, 20123, Milan, Italy.
Matteo CioccaNeurology Department, ASST Fatebenefratelli Sacco, Piazza Principessa Clotilde 3, 20123, Milan, Italy.
Giancarlo OlivaRadiology Department, ASST Fatebenefratelli Sacco, Piazza Principessa Clotilde 3, 20123, Milan, Italy.
Daniele GibelliDepartment of Biomedical Sciences for Health, Università degli Studi di Milano, Via Mangiagalli 31, 20121, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimOur aim was to assess MRI findings in the acute phase of ON and their correlation with visual acuity at presentation, visual outcome (VO) and MS development, to analyze a possible correlation between lesions number and diagnosis, and to assess correlation between orbits MRI and OCT. MATERIALS AND

methodsWe retrospectively studied 37 patients, who presented to our Emergency Department with an ON first episode from January 2015 to January 2017. Patients underwent immediately a complete neuro-ophthalmological evaluation, blood test, CSF analysis. MRI of brain, orbits, cervical spine was executed within 7 days from ON onset. Brain MRI was classified as: normal, non-specific, suspected demyelination, lesions with dissemination in space and time. Optic nerves findings were localized in three sites (intra-orbital, canalicular and chiasmal) and classified as: normal, STIR- alteration, altered contrast enhancement. Patients underwent neuro-ophthalmological follow-up and MRI at 6 months to assess VO (complete recovery, partial recovery, deficit persistence). Another follow-up at 1 year was performed to identify MS or clinically isolated syndrome (CIS).

results64.8% patients received a diagnosis of MS; 35% of CIS. Lesions of the optic nerve were found in 65.8%. We observed statistically significant correlation between brain MRI pattern and diagnosis and between lesions number and diagnosis. We observed a statistically significant correlation between orbital MRI pattern and optical coherence tomography (OCT) results. MRI brain findings correlate with development of MS. MRI brain features and lesions number can predict the risk of MS conversion.

Indexed as

Magnetic Resonance ImagingAcute DiseaseAdultBrainDiagnostic Techniques, OphthalmologicalEmergency Service, HospitalFemaleFollow-Up StudiesHumansMaleMiddle AgedMultiple SclerosisOptic NerveOptic NeuritisRetrospective StudiesStatistics, NonparametricSteroidsMagnetic resonanceMRIMultiple sclerosisOptical coherence tomographyOptic neuritisVisual outcome

Identifiers

PMID31435862

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.