ArticleMolecular and cellular biochemistry2019
miR-940 regulates the inflammatory response of chondrocytes by targeting MyD88 in osteoarthritis.
Article in Molecular and cellular biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- CircTBX5 knockdown modulates the miR-558/MyD88 axis to alleviate IL-1β-induced inflammation, apoptosis and extracellular matrix degradation in chondrocytes via inactivating the NF-κB signaling.Journal of orthopaedic surgery and research · 2023Article
- Unique microRNA expression profiles in plasmic exosomes from intrahepatic cholestasis of pregnancy.BMC pregnancy and childbirth · 2023Article
- The circular RNA circ_0099630/miR-940/receptor-associated factor 6 regulation cascade modulates the pathogenesis of periodontitis.Journal of dental sciences · 2022Article
- LncRNA LINC00461 exacerbates myocardial ischemia-reperfusion injury via microRNA-185-3p/Myd88.Molecular medicine (Cambridge, Mass.) · 2022Article
- Article
- Identification and development of a novel 5-gene diagnostic model based on immune infiltration analysis of osteoarthritis.Journal of translational medicine · 2021Article
- DecreasedTranslational lung cancer research · 2021Article
- The non-coding RNA interactome in joint health and disease.Nature reviews. Rheumatology · 2021Review
- MiR-940 Serves as a Diagnostic Biomarker in Patients with Sepsis and Regulates Sepsis-Induced Inflammation and Myocardial Dysfunction.Journal of inflammation research · 2021Article
- Development of a Novel Immune Infiltration-Related ceRNA Network and Prognostic Model for Sarcoma.Frontiers in cell and developmental biology · 2021Article
- LEF1 mediates osteoarthritis progression through circRNF121/miR-665/MYD88 axis via NF-кB signaling pathway.Cell death & disease · 2020Article
- MicroRNA-1202 plays a vital role in osteoarthritis via KCNQ1OT1 has-miR-1202-ETS1 regulatory pathway.Journal of orthopaedic surgery and research · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis (OA) has been identified to be one of the most prevalent forms of joint disorders, marked with inflammatory immune response that may give rise to several complications including disability. Numbers of investigations have proven that microRNA play a key role in chondrogenesis regulation. Accordingly, the current study was intended to explore more about the potential role of miR-940 in the regulation of immune response, pertaining to osteoarthritis. Our findings indicated miR-940 associated down-regulation in both, the tissue as well as at cellular levels, i.e. chondrocytes that are being induced with IL-1β. However, the expression of MyD88 was found to be opposite. Moreover, our findings indicated that miR-940 targets MyD88 to regulate its expression. The study was based on the proposition that normal human chondrocytes when induced with IL-1β significantly enhanced the level of inflammation along with simultaneous stimulation of NF-κB signaling mechanism. Alternatively, siRNA against MyD88, miR-940 mimic or the NF-κB inhibitor, reversed the effect of IL-1β. The chondrocytes that were transfected with miR-940 inhibitor increased the secretion of inflammatory cytokines and activated NF-κB. Furthermore, the expression of miR-490 was reduced in vivo, which was increased through an injection of lentivirus, to foster the production of necessary cytokines and NF-κB and the down-regulation of MyD88. In conclusion, the pathogenesis of OA can be regulated by miR-940/MyD88 axis, which can be achieved through the combined signaling mechanism of MyD88/NF-κB signaling, induced with the help of IL-1β.
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