ArticleJournal of general internal medicine2019
Prevalence of Activity Limitations and Association with Multimorbidity Among US Adults 50 to 64 Years Old.
Article in Journal of general internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 77 citations in OpenAlex.
- Association of Sustained Blood Pressure Control with Multimorbidity Progression Among Older Adults.Journal of the American Geriatrics Society · 2020Trial
- A secondary analysis of how changes in pain interference relate to changes in health-related quality of life and physical function in heart failure.Heart & lung : the journal of critical careTrial
- Associations of depressive symptoms and antidepressant medication use with physical function among middle-aged adults: Results from the CARDIA Function study.Journal of affective disorders · 2026Article
- Unique contributions of heart failure and chronic pain on physical function and quality of life in older adults.Geriatric nursing (New York, N.Y.) · 2026Article
- Sociodemographic and Health-Related Disparities in 24-Hr Movement Cycles Among Older Adult Women: The Study of Women's Health Across the Nation.Journal of aging and physical activity · 2026Article
- Middle-age healthcare spending and utilization at the intersection of comorbidities, functional limitation, and race/ethnicity.Innovation in aging · 2026Article
- Frailty and multimorbidity among adults aged 40-69 years in Montenegro: a cross-sectional pilot study.BMJ open · 2025Article
- The association between mobility and a cognitive measure of attention and processing speed in middle-aged adults: a cross-sectional study.Scientific reports · 2025Article
- Development of a physical performance summary score in middle age: Findings from the CARDIA Function study.American journal of epidemiology · 2025Article
- Association of multimorbidity trajectories from early adulthood through middle age with middle-age physical function.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Multimorbidity in dementia: Current perspectives and future challenges.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- The Epidemiology of Mobility Difficulty in Saudi Arabia: National Estimates, Severity Levels, and Sociodemographic Differentials.Healthcare (Basel, Switzerland) · 2025Article
- Smartphone-Based Analysis for Early Detection of Aging Impact on Gait and Stair Negotiation: A Cross-Sectional Study.Sensors (Basel, Switzerland) · 2025Article
- Limitations in Activities of Daily Living Among Individuals With Systemic Lupus Erythematosus.Arthritis care & research · 2025Article
- Prevalence of functional disability and associated factors among older people in Vietnam: a secondary data analysis.BMJ open · 2025Article
- Multimorbidity Trajectories From Early to Middle Adulthood and Physical Activity.American journal of preventive medicine · 2025Article
- Effectiveness of Keeogo Exoskeleton-Assisted Rehabilitation on Functional Mobility in Older Adults with Multimorbidity: A Single-Arm Pilot Study.International journal of general medicine · 2025Article
- Uncovering unseen ties: a network analysis explores activities of daily living limitations and depression among Chinese older adults.Frontiers in aging neuroscience · 2025Article
- Use of the Brief-BESTest partially instrumented with accelerometry to detect balance deterioration in middle-age.Aging clinical and experimental research · 2024Article
- The bidirectional association between the disability in activities of daily living and depression: a longitudinal study in Chinese middle-aged and older adults.BMC public health · 2024Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundFunctional limitations may be more common in middle-aged adults than previously recognized. However, there are few published data on the prevalence of activity limitations, and their association with multimorbidity, among adults 50 to 64 years old.
objectiveTo describe the prevalence of activity limitations and the association with multimorbidity in middle-aged adults.
designCross-sectional analysis of US population-based National Health and Nutrition Examination Survey (NHANES) 2011-2016.
participantsThe total number of community-dwelling NHANES participants aged 50-64 years old is 4217. MAIN MEASURES: Chronic conditions included hypertension, high cholesterol, diabetes mellitus, obesity, chronic kidney disease, cancer, stroke, coronary heart disease, heart failure, chronic obstructive pulmonary disease/asthma, arthritis, and depression. Activity limitations were defined as any difficulty within each of four International Classification of Functioning (ICF) domains: functional limitations (kneeling, carrying, standing, sitting, reaching, grasping, pulling), mobility (walking ¼ mile, climbing 10 steps), basic activities of daily living (BADLs; walking, transferring, eating, dressing), and instrumental activities of daily living (IADLs; finances, chores, cooking). We calculated prevalence ratios for activity limitations using generalized estimating equations. KEY
resultsThe prevalence of functional limitations, mobility limitations, BADL difficulty, and IADL difficulty was 34%, 11%, 15%, and 17%, respectively. Seventy-two percent of participants had two or more chronic conditions; 23% had two, 18% had three, 15% had four, and 16% had five or more. Multivariable adjusted prevalence ratios (95% CI) for functional limitations among those with 2, 3, 4, and 5 or more chronic conditions, compared with 0-1 conditions, were 1.94 (1.43-2.63), 2.50 (1.93-3.23), 3.26 (2.48-4.27), and 4.54 (3.48-5.93), respectively (p trend < 0.001). Larger prevalence ratios at a higher number of chronic conditions were present for mobility limitations, BADL difficulty, and IADL difficulty.
conclusionsProblems with function are not limited to older adults and multimorbidity may be helpful for identifying middle-aged adults with a high prevalence of activity limitations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.