Evidence map›Paper›PMID 31435641›Full record

ArticleThe American journal of clinical nutrition2019

Associations of dairy product consumption with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Italy cohort.

Valeria Pala, Sabina Sieri, Paolo Chiodini, Giovanna Masala, Domenico Palli, Amalia Mattiello, Salvatore Panico, Rosario Tumino, Graziella Frasca, Francesca Fasanelli and 4 more

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In one paragraph

Article in The American journal of clinical nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 10 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. The doseFrontiers in nutrition · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Valeria PalaEpidemiology and Prevention Unit, IRCCS National Cancer Institute Foundation, Milan, Italy.
Sabina SieriEpidemiology and Prevention Unit, IRCCS National Cancer Institute Foundation, Milan, Italy.
Paolo ChiodiniMedical Statistics Unit, Luigi Vanvitelli University of Campania, Naples, Italy.
Giovanna MasalaCancer Risk Factors and Lifestyle Epidemiology Unit, ISPRO, Florence, Italy.
Domenico PalliCancer Risk Factors and Lifestyle Epidemiology Unit, ISPRO, Florence, Italy.
Amalia MattielloDepartment of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
Salvatore PanicoDepartment of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
Rosario TuminoCancer Registry, ASP Ragusa, Ragusa, Italy.
Graziella FrascaCancer Registry, ASP Ragusa, Ragusa, Italy.
Francesca FasanelliUnit of Cancer Epidemiology, CeRMS, Department of Medical Sciences, University of Turin, Turin, Italy.
Fulvio RicceriDepartment of Clinical and Biological Sciences, University of Turin, Turin, Italy.
Claudia AgnoliEpidemiology and Prevention Unit, IRCCS National Cancer Institute Foundation, Milan, Italy.
Sara GrioniEpidemiology and Prevention Unit, IRCCS National Cancer Institute Foundation, Milan, Italy.
Vittorio KroghEpidemiology and Prevention Unit, IRCCS National Cancer Institute Foundation, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe relation of dairy product consumption to health and mortality is controversial.

objectivesWe investigated associations of consumption of various dairy products with mortality in the Italian cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-Italy study.

methodsDairy product consumption was assessed by validated semiquantitative FFQs. Multivariable Cox models stratified by center, age, and sex and adjusted for confounders estimated associations of milk (total, full fat, and reduced fat), yogurt, cheese, butter, and dairy calcium consumption with mortality for cancer, cardiovascular disease, and all causes. Nonlinearity was tested by restricted cubic spline regression.

resultsAfter a median follow-up of 14.9 y, 2468 deaths were identified in 45,009 participants: 59% from cancer and 19% from cardiovascular disease. No significant association of consumption of any dairy product with mortality was found in the fully adjusted models. A 25% reduction in risk of all-cause mortality was found for milk intake from 160 to 120 g/d (HR: 0.75; 95% CI: 0.61, 0.91) but not for the highest (>200 g/d) category of intake (HR: 0.95; 95% CI: 0.84, 1.08) compared with nonconsumption. Associations of full-fat and reduced-fat milk consumption with all-cause and cause-specific mortality were similar to those for milk as a whole.

conclusionsIn this Italian cohort characterized by low to average milk consumption, we found no evidence of a dose-response association between milk consumption and mortality and also no association of consumption of other dairy products investigated with mortality.

Indexed as

Dairy ProductsAnimalsCardiovascular DiseasesCause of DeathHumansMiddle AgedMilkNeoplasmsProportional Hazards ModelsProspective Studiescancercardiovascular diseasedairy product consumptionEPIC-Italymortality

Identifiers

PMID31435641

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.