ArticleMedical devices & sensors2018
High-speed Intraoperative Assessment of Breast Tumor Margins by Multimodal Ultrasound and Photoacoustic Tomography.
Article in Medical devices & sensors, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Artificial intelligence in the radiologic assessment of ductal carcinomaFrontiers in oncology · 2026Pooled it
- No cancer left behind: a testbed and demonstration of concept for photoacoustic tumor bed inspection.Computer assisted surgery (Abingdon, England) · 2026Article
- Investigation of feasibility and diagnostic capability of ultrasound-guided photoacoustic tomography for breast surgical margins.Npj imaging · 2026Article
- Recent advancements in molecular photoacoustic tomography.JPhys photonics · 2025Review
- Advanced vibrational microscopes for life science.Nature methods · 2025Review
- Inspiring a convergent engineering approach to measure and model the tissue microenvironment.Heliyon · 2024Review
- Advanced nanomaterials for imaging of eye diseases.ADMET & DMPK · 2024Review
- Investigating the feasibility of a hand-held photoacoustic imaging probe for margin assessment during breast conserving surgery.Photoacoustics · 2022Article
- Clear cell renal cell carcinoma detection by multimodal photoacoustic tomography.Photoacoustics · 2021Article
- Optoacoustic characterization of breast conserving surgery specimens - A pilot study.Photoacoustics · 2020Article
- Ultrasound Guided Optoacoustic Tomography in Assessment of Tumor Margins for Lumpectomies.Translational oncology · 2020Article
- A review of clinical photoacoustic imaging: Current and future trends.Photoacoustics · 2019Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
Conventional methods for breast tumor margins assessment need a long turnaround time, which may lead to re-operation for patients undergoing lumpectomy surgeries. Photoacoustic tomography (PAT) has been shown to visualize adipose tissue in small animals and human breast. Here, we demonstrate a customized multimodal ultrasound and PAT system for intraoperative breast tumor margins assessment using fresh lumpectomy specimens from 66 patients. The system provides the margin status of the entire excised tissue within 10 minutes. By subjective reading of three researchers, the results show 85.7% [95% confidence interval (CI), 42.0% - 99.2%] sensitivity and 84.6% (95% CI, 53.7% - 97.3%) specificity, 71.4% (95% CI, 30.3% - 94.9%) sensitivity and 92.3% (95% CI, 62.1% - 99.6%) specificity, and 100% (95% CI, 56.1% - 100%) sensitivity and 53.9% (95% CI, 26.1% - 79.6%) specificity respectively when cross-correlated with post-operational histology. Furthermore, a machine learning-based algorithm is deployed for margin assessment in the challenging ductal carcinoma
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.