ArticleInternational journal of reproductive biomedicine2019
The therapeutic potential of amifostine on cyclophosphamide-induced testicular dysfunction in rats: An experimental study.
Article in International journal of reproductive biomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Hyperbaric oxygen therapy in a rat model of cyclophosphamide-induced hemorrhagic cystitis.International urology and nephrology · 2026Article
- Azilsartan as a preventive agent against cyclophosphamide-induced testicular injury in male rats.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Hepatoprotective effect of amifostine and WR-1065 on acetaminophen-induced liver toxicity on Wistar rats.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Preventive effects of quercetin against inflammation and apoptosis in cyclophosphamide-induced testicular damage.Iranian journal of basic medical sciences · 2024Article
- Counteractive effects of extracts ofHeliyon · 2023Article
- Frankincense extract protects against testicular damage through augmentation of antioxidant defense mechanisms and modulation of apoptotic genes expression.Scientific reports · 2022Article
- Exploring the main effects ofVeterinary research forum : an international quarterly journal · 2022Article
- Immunomodulatory effects of selenium-enriched peptides from soybean in cyclophosphamide-induced immunosuppressed mice.Food science & nutrition · 2021Article
- Morin-5'-Sulfonic Acid Sodium Salt (NaMSA) Attenuates Cyclophosphamide-Induced Histological Changes in Genitourinary Tract in Rats-Short Report.Pharmaceuticals (Basel, Switzerland) · 2021Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCyclophosphamide (CP) is a well-known alkylating anticancer agent used in the treatment of various malignant and non-malignant tumors. CP may also cause a variety of adverse effects, including reproductive toxicity. Amifostine is known as a cytoprotective drug having antioxidant properties.
objectiveTo evaluate the possible beneficial effects of amifostine on testicular toxicity induced by CP in rats. MATERIALS AND
methodsA total of 35 Sprague-Dawley rats were used in this experimental study. The CP group animals received a single dose of 200 mg/kg CP on Day 8 by intraperitoneal injection and were left untreated for the following seven days. The two remaining groups of animals were treated with 200 mg/kg/day amifostine (AMF 200) and 400 mg/kg/day amifostine (AMF 400) for seven days prior to and following a single intraperitoneal injection of CP. Morphometrical analysis and histological examination of testicular tissue were performed. Serum testosterone, luteinizing hormone, and follicle-stimulating hormone levels were measured in serum using commercial ELISA kits. The epidydimal sperm count was determined.
resultsThe tubular epithelial height in the testis was significantly higher in the AMF400 group compared to other groups (p
conclusionAmifostine, at a dose of 400 mg/kg, may have a protective effect on testicular damage induced by CP in rats.
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