ArticleChronic stress (Thousand Oaks, Calif.)
Frontal Lobe Circuitry in Posttraumatic Stress Disorder.
Article in Chronic stress (Thousand Oaks, Calif.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Functional brain changes after alternative pharmacological interventions in posttraumatic stress disorder: A systematic review of clinical trials.Brain and behavior · 2023Pooled it
- Reduced Gray-White Matter Contrast in Chronic Posttraumatic Stress Disorder in World Trade Center Responders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Positive association between local brain hypercorrelations and posttraumatic stress disorder symptom severity.Journal of neurophysiology · 2026Article
- History of Trauma Exposure and Post-Traumatic Stress Spectrum Symptoms in a Sample of Bariatric Surgery Candidates: Clinical Correlates and Association with Maladaptive Eating Behaviours.International journal of environmental research and public health · 2026Observational
- Neural activity is altered by childhood trauma exposure and varied by sex in typically developing youths during sustained attention-to-response tasks (SART).Neuropsychologia · 2025Article
- Enhanced cognitive control following neurofeedback therapy in chronic treatment-resistant PTSD among refugees: a feasibility study.Frontiers in psychiatry · 2025Article
- Clinical conceptualisation of PTSD in psilocybin treatment: disrupting a pre-determined and over-determined maladaptive interpretive framework.Therapeutic advances in psychopharmacology · 2025Review
- Associations Between Social Network Characteristics and Brain Structure Among Older Adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Using lifestyle interventions and the gut microbiota to improve PTSD symptoms.Frontiers in neuroscience · 2024Review
- Intrusive thinking: Circuit and synaptic mechanisms of a transdiagnostic psychiatric symptom.Neuroscience and biobehavioral reviews · 2023Review
- A Neurobiological Framework for the Therapeutic Potential of Music and Sound Interventions for Post-Traumatic Stress Symptoms in Critical Illness Survivors.International journal of environmental research and public health · 2022Review
- Gene expression in the dorsolateral and ventromedial prefrontal cortices implicates immune-related gene networks in PTSD.Neurobiology of stress · 2021Article
- Neurocircuitry of Contingency Awareness in Pavlovian Fear Conditioning.Cognitive, affective & behavioral neuroscience · 2021Article
- Dysregulation of inflammation, neurobiology, and cognitive function in PTSD: an integrative review.Cognitive, affective & behavioral neuroscience · 2020Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Symptoms of posttraumatic stress disorder include hyperarousal, avoidance of trauma-related stimuli, re-experiencing of trauma, and mood changes. This review focuses on the frontal cortical areas that form crucial links in circuitry pertinent to posttraumatic stress disorder symptomatology: (1) the conditioned fear extinction circuit, (2) the salience circuit, and (3) the mood circuit. These frontal areas include the ventromedial prefrontal cortex (conditioned fear extinction), the dorsal anterior cingulate and insular cortices (salience), and the lateral orbitofrontal and subgenual cingulate cortices (mood). Frontal lobe structural abnormalities in posttraumatic stress disorder, including volumetric reductions in the cingulate cortices, impact all three circuits. Functional analyses of frontal cortices in posttraumatic stress disorder show abnormal activation in all three according to task demand and emotional valence. Network analyses reveal altered amygdalo-frontal connectivity and failure to suppress the default mode network during cognitive engagement. Spine shape alterations also have been detected in the medial orbito-frontal cortex in posttraumatic stress disorder postmortem brains, suggesting reduced synaptic plasticity. Importantly, frontal lobe abnormalities in posttraumatic stress disorder extend beyond emotion-related circuits to include the lateral prefrontal cortices that mediate executive functions. In conclusion, widespread frontal lobe dysfunction in posttraumatic stress disorder provides a neurobiologic basis for the core symptomatology of the disorder, as well as for executive function impairment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.