ArticleSpine surgery and related research2018
The Difference in Gender Affects the Pathogenesis of Ligamentum Flavum Hypertrophy.
Article in Spine surgery and related research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Prevalence and Demographic Associations of Ligamentum Flavum Hypertrophy in Lumbar Spinal Stenosis.Orthopedic research and reviews · 2026Article
- Insulin Resistance as a Risk Factor for Flavum Hypertrophy in Lumbar Spinal Stenosis.Spine surgery and related research · 2024Article
- Experimental confirmation and bioinformatics reveal biomarkers of immune system infiltration and hypertrophy ligamentum flavum.JOR spine · 2024Article
- The hypertrophy of the cervical ligamentum flavum results in incomplete paralysis of both lower limbs: A case report.International journal of surgery case reports · 2023Article
- Administration of N-Acetylcysteine to Regress the Fibrogenic and Proinflammatory Effects of Oxidative Stress in Hypertrophic Ligamentum Flavum Cells.Oxidative medicine and cellular longevity · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionGender differences may play a role in the pathogenesis of lumbar spinal stenosis. However, few reports that discuss the effects of gender differences in ligamentum flavum (LF) hypertrophy have been published, and no study has investigated the relationship between LF thickness and the quantitative value of intervertebral disc (IVD) degeneration. This study aimed to investigate the impact of gender on the pathomechanisms underlying LF hypertrophy, focusing on the relationship among LF thickness, IVD degeneration, and age.
methodsThe subjects include 100 patients with low back pain and leg numbness, tingling, or pain. We measured LF thickness and the T2 values of IVDs using MR imaging and analyzed the relationship among LF thickness, T2 values of IVDs, and age. The interclass correlation coefficient (ICC) was calculated as the inter-rater reliability between the LF thickness values measured by two investigators.
resultsICC was calculated for the two measurements of LF thickness (r = 0.923, 95% CI: 0.907-0.936). No statistically significant difference in the T2 values of IVDs was observed between females and males from L2/3 to L5/S. There were significantly negative linear correlations between LF thickness and the T2 values of IVDs at all levels, but this correlation was not observed in females at L4/5. There were significantly negative linear correlations between age and the T2 values of IVDs from L2/3 to L5/S for all patients, females, and males (r = 0.422-0.756). In addition, there were significantly positive linear correlations between age and LF thickness from L2/3 to L4/5 for all patients (r = 0.329-0.361) and females (r = 0.411-0.481). Correlations were not observed for males at all levels or for all patients at L5/S.
conclusionsThe relationships identified among LF thickness, age, and IVD degeneration suggest that gender differences play a role in the pathogenesis of LF hypertrophy.
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