ArticleFatigue : biomedicine, health & behavior2018
Latent class analysis of a heterogeneous international sample of patients with myalgic encephalomyelitis/chronic fatigue syndrome.
Article in Fatigue : biomedicine, health & behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Recent research in myalgic encephalomyelitis/chronic fatigue syndrome: an evidence map.Health technology assessment (Winchester, England) · 2025Pooled it
- Symptom clusters in ME/CFS reflect distinct neuroimmune and autonomic pathophysiological mechanisms: a translational model.Journal of translational medicine · 2026Article
- Replicated blood-based biomarkers for myalgic encephalomyelitis not explicable by inactivity.EMBO molecular medicine · 2025Article
- [What Medical Specialties do ME/CFS Sufferers Consult? A Public Health Study on the need for Better Medical Education and Training].Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)) · 2024Article
- [Systems thinking, subjective findings and diagnostic "pigeonholing" in ME/CFS: A mainly qualitative public health study from a patient perspective].Deutsche medizinische Wochenschrift (1946) · 2024Article
- What Long COVID investigators can learn from four decades of ME/CFS research.Brain behavior and immunity integrative · 2023Article
- Symptom-based clusters in people with ME/CFS: an illustration of clinical variety in a cross-sectional cohort.Journal of translational medicine · 2023Article
- The importance of estimating prevalence of ME/CFS in future epidemiological studies of long COVID.Frontiers in public health · 2023Article
- Typing myalgic encephalomyelitis by infection at onset: A DecodeME study.NIHR open research · 2023Article
- Article
- Are there subgroups of chronic fatigue syndrome? An exploratory cluster analysis of biological markers.Journal of translational medicine · 2021Article
- The Development of the DePaul Symptom Questionnaire: Original, Expanded, Brief, and Pediatric Versions.Frontiers in pediatrics · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundIndividuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) routinely display differences in symptomatology, as well as illness course, onset, duration, and functional disability. Given such diversity, previous work has attempted to identify symptom-based ME/CFS subtypes. However, results have been inconsistent. PURPOSE: This study sought to elucidate potential subtypes of ME/CFS as well as explore the impact of subtype membership on health functioning.
methodsTwelve non-core (i.e., less frequently endorsed) symptoms were included in a latent class analysis of 1,210 adults with ME/CFS. Demographic and illness-related predictors of class membership were evaluated with a multinomial logistic regression. ANOVAs were then performed to determine if there were significant differences across class on the eight subscales of the Short-Form Health Survey (SF-36).
resultsA six-class solution was selected, which consisted of one class that was likely to endorse all non-core symptoms, one class that was unlikely to endorse any non-core symptoms, and four classes that were likely to endorse either one or two non-core symptom domains (i.e., circulatory/neuroendocrine impairment, orthostatic intolerance, and gastro-intestinal distress). Significant functioning differences by class were present for all SF-36 subscales.
conclusionsThese results are suggestive of subtypes of ME/CFS and, if replicated, may assist physicians in providing tailored treatment to patients and allow researchers to form more homogeneous samples.
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