ArticleJournal of Taibah University Medical Sciences2019
Audiometric notch for the prediction of early occupational hearing loss and its association with the interleukin-1beta genotype.
Article in Journal of Taibah University Medical Sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 10 citations in OpenAlex.
- Uncovering Novel Prognostic Factors of Sudden Sensorineural Hearing Loss by Whole-Genome Sequencing of Cell-Free DNA.The journal of international advanced otology · 2022Article
- Association of heat shock protein70-2 genotypes with hypertension among textile workers occupationally exposed to noise.Environmental science and pollution research international · 2022Article
- Analysis of Studies in Tinnitus-Related Gene Research.Noise & healthReview
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesNoise-induced hearing loss (NIHL) is a frequent and irreversible industrial-health problem, the early diagnosis of which can prevent hearing deterioration, especially of speech frequencies. This study aimed to assess hearing impairment in workers occupationally exposed to noise. Audiometric notches and IL-1β gene polymorphisms were evaluated.
methodsThe study included 98 workers employed in a textile factory. Pure-tone audiometric testing was conducted for all workers, using a manual pure-tone diagnostic audiometer, and the noise level was measured at four different work sites in a spinning section. IL-1β gene polymorphism was determined using PCR-RFLP methods.
resultsWorkers were exposed to a mean noise level of 105.5 dB. As many as 27.6% of them complained of tinnitus and the majority suffered from some degree of hearing loss in either ear, but none of them exceeded 60 dB. Audiometric notches were detected in either one or both ears. Only 28.6% of workers showed the absence of notches. The TT genotype of IL-1β polymorphisms was dominant in 49% of the workers, whereas TC was predominant in 39.8% and CC in 11.2%. The CC genotype was associated with smoking (54.5%) and audiometric notches (100%). The IL-1β genotype distribution showed no significant difference with or without tinnitus.
conclusionThis study showed an association between the CC genotype and smoking as well as audiometric notches in workers occupationally exposed to noise. Workers showing audiometric notches should be followed up regularly. Further studies are required to confirm the interrelationship amongst tinnitus, audiometric notches, and IL-1β genotypes.
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