ArticleJournal of Taibah University Medical Sciences2018
Biological investigation of novel metal complexes of 2-amino-4-substituted phenylthiazole Schiff bases.
Article in Journal of Taibah University Medical Sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Review on the Antibacterial Mechanism of Plant-Derived Compounds against Multidrug-Resistant Bacteria (MDR).Evidence-based complementary and alternative medicine : eCAM · 2021Review
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2 authors.
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Abstract
objectiveInvasive microorganisms and free radicals are responsible for the delayed healing of various infections. It is necessary to discovery of novel molecules that are effective against invasive microorganisms and inhibit free radicals. Therefore, a series of metal complexes of 2-amino-4-substituted phenylthiazole Schiff bases were synthesized.
methodsStructural characterization of the synthesized molecules was performed by elemental analysis, FT/IR,
resultsResults of the oral acute toxicity study revealed that the synthesized analogues are safe up to a dose of 2000 mg/kg body weight. The complexes bis[{4-((4-bromo-3-methylphenyl)diazenyl)-2-((4-phenylthiazol-2-ylimino)methyl)phenoxy}]cobalt (
conclusionThe results justify that the chelation of metals with Schiff base ligands enhances their biological activities against drug-resistant microbial strains.
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