Evidence map›Paper›PMID 31435270›Full record

ArticleJournal of Taibah University Medical Sciences2017

10-Gingerol as an inducer of apoptosis through HTR1A in cumulus cells:

Kiptiyah Kiptiyah, Widodo Widodo, Gatot Ciptadi, Aulanni'am Aulanni'am, Mohammad A Widodo, Sutiman B Sumitro

Open access · goldAbstract read
In one paragraph

Article in Journal of Taibah University Medical Sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kiptiyah KiptiyahDepartment of Biology, Faculty of Sciences and Technology, Maulana Malik Ibrahim Islamic State University of Malang, Indonesia.
Widodo WidodoDepartment of Biology, Faculty of Sciences, Brawijaya University, Malang, Indonesia.
Gatot CiptadiDepartment of Reproduction, Faculty of Husbandry, Brawijaya University, Malang, Indonesia.
Aulanni'am Aulanni'amDepartment of Chemistry, Faculty of Sciences, Brawijaya University, Malang, Indonesia.
Mohammad A WidodoDepartment of Pharmacology, Faculty of Medicine, Brawijaya University, Malang, Indonesia.
Sutiman B SumitroDepartment of Biology, Faculty of Sciences, Brawijaya University, Malang, Indonesia.
University of Brawijaya · IDUniversitas Islam Negeri Maulana Malik Ibrahim · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesCumulus cells play a crucial role as essential mediators in the maturation of ova. Ginger contains 10-gingerol, which induces apoptosis in colon cancer cells. Based on this hypothesis, this study aimed to determine whether 10-gingerol is able to induce apoptosis in normal cells, namely, cumulus cells.

methodsThis study used an

resultThe

conclusionsThese findings indicate that further examination is warranted for 10-gingerol as a contraception agent.

Indexed as

10-GingerolApoptosisARG, arginineCumulus cellseNOS, endothelial nitric oxide synthaseFOXO, forkhead boxGLU, glutamineGLY, glycineGSK3B, glycogen synthase kinase-3βHTR1AHTR1A, 5-hydroxytryptamine receptor 1 AILE, ileusineILK, integrin-linked kinaseIn silicoIn vitroLYS, lysineMDM2, murine double minute clone 2MET, methioninemTORC1, mTOR complex 1mTORC2, mTOR complex 2mTOR, mammalian target of rapamycinNO, nitric oxideNOS3, nitric oxide synthase 3PTEN, phosphatase and tensin homologue delete on chromosome tenRICTOR, rapamycin-insensitive companion of mTORTYR, tyrosine

Identifiers

PMID31435270
PMCPMC6695051
OpenAlexW2691594610

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.