Evidence map›Paper›PMID 31435035›Full record

ReviewBone marrow transplantation2020

Incidence and outcome of Kaposi sarcoma after hematopoietic stem cell transplantation: a retrospective analysis and a review of the literature, on behalf of infectious diseases working party of EBMT.

Simone Cesaro, Gloria Tridello, Steffie van der Werf, Peter Bader, Gerard Sociè, Per Ljungman, Grant McQuaker, Stefano Giardino, Duygu Uckan-Cetinkaya, Achilles Anagnostopoulos and 7 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Bone marrow transplantation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
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  9. Article
  10. The skin and soft tissue infections in hematological patients.Current opinion in infectious diseases · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Simone CesaroPediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy. simone.cesaro@aovr.veneto.it.
Gloria TridelloPediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.
Steffie van der WerfEBMT Data Office, Leiden, Netherlands.
Peter BaderUniversitaetsklinikum Frankfurt Goethe-Universitaet, Klinik für Kinder und Jugendmedizin, Frankfurt, Germany.
Gerard SocièHopital St. Louis, Paris, France.ORCID http://orcid.org/0000-0002-2114-7533
Per LjungmanKarolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-8281-3245
Grant McQuakerBone MarrowTransplant Unit, Glasgow, UK.
Stefano GiardinoIstituto Giannina Gaslini, Genova, Italy.
Duygu Uckan-CetinkayaHacettepe University Children's Hospital, Ankara, Turkey.
Achilles AnagnostopoulosGeorge Papanicolaou General Hospital, Thessaloniki, Greece.ORCID http://orcid.org/0000-0003-4384-9031
Hakan OzdoguBaskent University Hospital, Adana, Turkey.
Rik SchotsUniversitair Ziekenhuis Brussel, Brussels, Belgium.
Pavel JindraCharles University Hospital, Pilsen, Czech Republic.
Marco LadettoHospital SS.Antonio e Biagio, Alessandria, Italy.
Wilfried SchroyensAntwerp University Hospital (UZA), Antwerp, Belgium.
Malgorzata MikulskaOspedale San Martino, Genova, Italy.
Jan StyczynskiDepartment of Pediatric Hematology Oncology, University Hospital, Collegium Medicum UMK, Bydgoszcz, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence, the clinical characteristics, and the outcome of Kaposi sarcoma (KS) in patients after hematopoietic stem cell transplantation (HSCT) were assessed. During the period 1987-2018, 13 cases of KS were diagnosed, 3 females and 10 males, median age of 50 years, median time from HSCT of 7 months. KS had an incidence of 0.17% in allogeneic and 0.05% in autologous HSCT. HHV-8 was documented in eight of nine tumor tissue samples assessed. The organ involvement was: skin in nine, lymph nodes in six, oral cavity in four, and visceral in three patients, respectively; seven patients had >1 organ involved. Five patients had immunosuppression withdrawn, whereas four and three patients received radiotherapy and chemotherapy, respectively. Eight patients are alive (median follow-up 48 months, range 5-128), whereas five patients died after a median time of 8 months from the diagnosis of KS. However, no death was caused by KS. We conclude that the incidence of KS after HSCT is very low. Although KS can be managed with the reduction of immunosuppression, visceral forms may require chemotherapy and/or radiotherapy. The low prevalence of KS indicates that screening for HHV-8 serology and surveillance for HHV-8 viremia are not indicated in HSCT patients.

Indexed as

Communicable DiseasesHematopoietic Stem Cell TransplantationSarcoma, KaposiFemaleHumansIncidenceMaleMiddle AgedRetrospective Studies

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.