Evidence map›Paper›PMID 31435016›Full record

ArticleNature2019

Identification of an ATP-sensitive potassium channel in mitochondria.

Angela Paggio, Vanessa Checchetto, Antonio Campo, Roberta Menabò, Giulia Di Marco, Fabio Di Lisa, Ildiko Szabo, Rosario Rizzuto, Diego De Stefani

Open access · greenAbstract read
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 242 citations in OpenAlex.

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  11. Mitochondrial metabolism and cancer therapeutic innovation.Signal transduction and targeted therapy · 2025
    Review
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78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Angela PaggioDepartment of Biomedical Sciences, University of Padova, Padova, Italy.
Vanessa ChecchettoDepartment of Biology, University of Padova, Padova, Italy.
Antonio CampoDepartment of Biomedical Sciences, University of Padova, Padova, Italy.
Roberta MenabòCNR Institute of Neuroscience, Padova, Italy.
Giulia Di MarcoDepartment of Biomedical Sciences, University of Padova, Padova, Italy.
Fabio Di LisaDepartment of Biomedical Sciences, University of Padova, Padova, Italy.
Ildiko SzaboDepartment of Biology, University of Padova, Padova, Italy.
Rosario RizzutoDepartment of Biomedical Sciences, University of Padova, Padova, Italy. rosario.rizzuto@unipd.it.
Diego De StefaniDepartment of Biomedical Sciences, University of Padova, Padova, Italy. diego.destefani@gmail.com.
University of Padua · ITNeuroscience Institute · IT

Funding

TRANSLOCATION OF p66Shc: KINETICS, FUNCTION, APOPTOSISP01AG025532 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KIM, KYOUNGMI · 2007 to 2017
$12.1M
European Research Council 294777NIA NIH HHS P01 AG025532NIH HHS 1P01AG025532-01A1Telethon GGP16029
6 · The paper itself

Abstract

Mitochondria provide chemical energy for endoergonic reactions in the form of ATP, and their activity must meet cellular energy requirements, but the mechanisms that link organelle performance to ATP levels are poorly understood. Here we confirm the existence of a protein complex localized in mitochondria that mediates ATP-dependent potassium currents (that is, mitoK

Indexed as

Adenosine TriphosphateAnimalsCardiotonic AgentsDiazoxideElectrophysiological PhenomenaHeartIschemic Preconditioning, MyocardialMaleMembrane Potential, MitochondrialMiceMitochondria, HeartOrgan SizeOxidative PhosphorylationPotassiumPotassium ChannelsProtein SubunitsAdenosine TriphosphateCardiotonic AgentsDiazoxidemitochondrial K(ATP) channelPotassiumPotassium ChannelsProtein Subunits

Identifiers

PMID31435016
PMCPMC6726485
OpenAlexW2969814176

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.