Evidence map›Paper›PMID 31435012›Full record

ArticleNature2019

DEAD-box ATPases are global regulators of phase-separated organelles.

Maria Hondele, Ruchika Sachdev, Stephanie Heinrich, Juan Wang, Pascal Vallotton, Beatriz M A Fontoura, Karsten Weis

Open access · greenAbstract read
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 256 papers.

0numbers the graph read from it
0cells of the map it votes in
256citing papers in PubMed
18.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

256 citing papers in PubMed, 445 citations in OpenAlex.

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  14. A unified photosensitizer platform forbioRxiv : the preprint server for biology · 2026
    Article
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196 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Maria HondeleInstitute of Biochemistry, ETH Zurich, Zurich, Switzerland.
Ruchika SachdevInstitute of Biochemistry, ETH Zurich, Zurich, Switzerland.
Stephanie HeinrichInstitute of Biochemistry, ETH Zurich, Zurich, Switzerland.
Juan WangDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Pascal VallottonInstitute of Biochemistry, ETH Zurich, Zurich, Switzerland.
Beatriz M A FontouraDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Karsten WeisInstitute of Biochemistry, ETH Zurich, Zurich, Switzerland. karsten.weis@bc.biol.ethz.ch.
ETH Zurich · CHThe University of Texas Southwestern Medical Center · US

Funding

Swiss National Science Foundation 159731
6 · The paper itself

Abstract

The ability of proteins and nucleic acids to undergo liquid-liquid phase separation has recently emerged as an important molecular principle of how cells rapidly and reversibly compartmentalize their components into membrane-less organelles such as the nucleolus, processing bodies or stress granules

Indexed as

Cell CompartmentationAdenosine TriphosphatasesBiocatalysisCell LineConserved SequenceCytoplasmic GranulesDEAD-box RNA HelicasesEukaryotic CellsEvolution, MolecularHumansOrganellesProkaryotic CellsRNARNA TransportSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAdenosine TriphosphatasesDDX4 protein, humanDEAD-box RNA HelicasesDHH1 protein, S cerevisiaeRNARNA-dependent ATPaseSaccharomyces cerevisiae Proteins

Identifiers

PMID31435012
PMCPMC7617057
OpenAlexW2969343565

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.