ArticleJournal of human hypertension2020
Age-specific reference values for carotid arterial stiffness estimated by ultrasonic wall tracking.
Article in Journal of human hypertension, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Ambulatory and successive home-based heart rate targeted aerobic training improves arterial parameters: a follow-up study in people with metabolic syndrome.Annals of medicine · 2023Trial
- Observational
- Monitoring carotid arterial stiffness using non-contrast-enhanced 4D MR angiography.European radiology experimental · 2026Article
- Skin-adaptive focused flexible micromachined ultrasound transducers for wearable cardiovascular health monitoring.Science advances · 2025Article
- The Link Between Venous and Arterial Thrombosis: Is There a Role for Endothelial Dysfunction?Cells · 2025Review
- The Effect of Age, Hypertension, and Overweight on Arterial Stiffness Assessed Using Carotid Wall Echo-Tracking in Childhood and Adolescence.Life (Basel, Switzerland) · 2024Article
- Quantifying carotid stiffness in chronic kidney disease using ultrafast ultrasound imaging.Quantitative imaging in medicine and surgery · 2024Article
- Early Cardiac Rehabilitation Improves Carotid Arterial Stiffness in Patients with Myocardial Infarction.Clinical interventions in aging · 2024Article
- Fully automatic carotid arterial stiffness assessment from ultrasound videos based on machine learning.Physical and engineering sciences in medicine · 2023Article
- Determinants of Arterial Stiffness in Patients with Morbid Obesity. The Role of Echocardiography and Carotid Ultrasound Imaging.Medicina (Kaunas, Lithuania) · 2023Article
- Effects of Carotid Artery Stiffness on Cerebral Small-Vessel Disease and Cognition.Journal of the American Heart Association · 2022Article
- Estimation of Aortic Stiffness with Bramwell-Hill Equation: A Comparative Analysis with Carotid-Femoral Pulse Wave Velocity.Bioengineering (Basel, Switzerland) · 2022Article
- Six-month longitudinal tracking of arterial stiffness and blood pressure in young adults following SARS-CoV-2 infection.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Age-changes in right ventricular function-pulmonary circulation coupling: from pediatric to adult stage in 1899 healthy subjects. The RIGHT Heart International NETwork (RIGHT-NET).The international journal of cardiovascular imaging · 2021Article
- Vascular Ageing and Aerobic Exercise.International journal of environmental research and public health · 2021Review
- Circulating calcification inhibitors are associated with arterial damage in pediatric patients with primary hypertension.Pediatric nephrology (Berlin, Germany) · 2021Article
- Assessment of Carotid Arterial Stiffness in Community Settings With ARTSENS®.IEEE journal of translational engineering in health and medicine · 2021Article
- Subject-Specific Pressure Normalization of Local Pulse Wave Velocity: Separating Intrinsic From Acute Load-Dependent Stiffening in Hypertensive Patients.Frontiers in physiology · 2021Article
- Exercise Training Duration and Intensity Are Associated With Thicker Carotid Intima-Media Thickness but Improved Arterial Elasticity in Active Children and Adolescents.Frontiers in cardiovascular medicine · 2021Article
- Carotid Artery Stiffness in Metabolic Syndrome: Sex Differences.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
19 authors at 13 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interaction between arterial stiffness and hypertension plays an important role in the development of cardiovascular disease. Accordingly, assessment of arterial stiffness may provide a tool for estimating cardiovascular risk and monitoring therapy in hypertensive patients. Radiofrequency-based vascular ultrasound allows accurate noninvasive assessment of local mechanical properties of large arteries, but for its use in clinical practice, reference values according to age and sex are mandatory for each vascular site. To provide reference values for common carotid artery stiffness as assessed by an echo-tracking imaging system Hitachi-Aloka, we pooled measurements collected in 1847 healthy subjects aged 3-74 years (1008 males and 839 females) recruited in 14 European centers in the E-tracking International Collaboration (ETIC). Statistical models were developed to describe relationships of different stiffness indices with age and to calculate median values and Z-scores corresponding to ± 1 and ± 2 standard deviations. In our apparently healthy population, age accounted for 53% of variability in the elastic modulus (epsilon), 39% in arterial compliance, 47% in stiffness index (β), and 56% in local pulse wave velocity; on average, blood pressure accounted for a further 7.5% of variability. Dependence on age was not linear; changes in mean values increased at older ages, especially for epsilon and β. There was an interaction between age and gender for arterial compliance, which was higher in males. We present nomograms and a software that can be used for the automated calculation of Z-scores for local carotid stiffness in individual patients. These tools can be used to establish prognostic indicators or surrogate targets for treatment monitoring.
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