ArticleMucosal immunology2020
Antibiotic-induced dysbiosis of gut microbiota impairs corneal development in postnatal mice by affecting CCR2 negative macrophage distribution.
Article in Mucosal immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Sleep deprivation disrupts lacrimal gland homeostasis via hypothalamic-pituitary-adrenal axis and gut dysbiosis in mice.Communications biology · 2026Article
- Antibiotic-induced microbiota depletion impairs the proregenerative response to a biological scaffold.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- NF-κB/IL-6 axis drives impaired corneal wound healing in aqueous-deficient dry eye.Frontiers in immunology · 2025Article
- Multidimensional immunotherapy for dry eye disease: current status and future directions.Frontiers in ophthalmology · 2024Review
- Article
- Delayed Microbial Maturation Durably Exacerbates Th17-driven Asthma in Mice.American journal of respiratory cell and molecular biology · 2023Article
- Ocular microbiota promotes pathological angiogenesis and inflammation in sterile injury-driven corneal neovascularization.Mucosal immunology · 2022Article
- Gut Microbiota Dysbiosis Induced by Decreasing Endogenous Melatonin Mediates the Pathogenesis of Alzheimer's Disease and Obesity.Frontiers in immunology · 2022Article
- High fat diet induced gut dysbiosis alters corneal epithelial injury response in mice.The ocular surface · 2022Article
- Depletion of gut microbiota improves the therapeutic efficacy of cancer nanomedicine.Theranostics · 2022Article
- Short-Term High Fructose Intake Impairs Diurnal Oscillations in the Murine Cornea.Investigative ophthalmology & visual science · 2021Article
- Two Antibiotics, Ampicillin and Tetracycline, Exert Different Effects in HT-29 Colorectal Adenocarcinoma Cells in Terms of Cell Viability and Migration Capacity.Current oncology (Toronto, Ont.) · 2021Article
- Resident Innate Immune Cells in the Cornea.Frontiers in immunology · 2021Review
- Microbiota-host interactions shape ageing dynamics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- The gut-eye-lacrimal gland-microbiome axis in Sjögren Syndrome.The ocular surface · 2020Review
- Article
- Neutrophil L-Plastin Controls Ocular Paucibacteriality and Susceptibility to Keratitis.Frontiers in immunology · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotics are extremely useful, but they can cause adverse impacts on host bodies. We found that antibiotic treatment altered the composition of the gut microbiota and the gene expression profile in the corneal tissues of postnatal mice and decreased the corneal size and thickness, the angiogenesis of limbal blood vessels, and the neurogenesis of corneal nerve fibers. The reconstitution of the gut microbiota with fecal transplants in antibiotic-treated mice largely reversed these impairments in corneal development. Furthermore, C-C chemokine receptor type 2 negative (CCR2
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Registered trials
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