ArticleScientific reports2019
Microridges are apical epithelial projections formed of F-actin networks that organize the glycan layer.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 59 citations in OpenAlex.
- Integrated Sensory and Immune Cell Organization in the Lip Skin of the Goldfish (Animals : an open access journal from MDPI · 2026Article
- mTOR signaling governs the formation of epithelial apical projections via S6K1-RhoA and aPKC-Lgl2 axes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- INHAND: Non-proliferative and proliferative lesions of fish - Chapter 7. Fish integumentary system.Journal of toxicologic pathology · 2026Article
- Article
- Phased ERK responsiveness and developmental robustness regulate teleost skin morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Spontaneous Calcium Bursts Organize the Apical Actin Cytoskeleton of Multiciliated Cells.International journal of molecular sciences · 2025Article
- The gustatory stalk of the Remo flounder exemplifies how complex evolutionary novelties may arise.Scientific reports · 2024Article
- Parasitic fish embryos do a "front-flip" on the yolk to resist expulsion from the host.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A deep learning framework for quantitative analysis of actin microridges.NPJ systems biology and applications · 2023Article
- A transient apical extracellular matrix relays cytoskeletal patterns to shape permanent acellular ridges on the surface of adult C. elegans.PLoS genetics · 2022Article
- Chemical fixation creates nanoscale clusters on the cell surface by aggregating membrane proteins.Communications biology · 2022Article
- Microridge-like structures anchor motile cilia.Nature communications · 2022Article
- Unilateral zebrafish corneal injury induces bilateral cell plasticity supporting wound closure.Scientific reports · 2022Article
- Stochastic contraction of myosin minifilaments drives evolution of microridge protrusion patterns in epithelial cells.Molecular biology of the cell · 2021Article
- Key Genes Regulating Skeletal Muscle Development and Growth in Farm Animals.Animals : an open access journal from MDPI · 2021Review
- Olfactory Rod Cells: A Rare Cell Type in the Larval Zebrafish Olfactory Epithelium With a Large Actin-Rich Apical Projection.Frontiers in physiology · 2021Article
- Tools of the trade: studying actin in zebrafish.Histochemistry and cell biology · 2020Review
- ThePhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Keratins and the plakin family cytolinker proteins control the length of epithelial microridge protrusions.eLife · 2020Article
- Cortical contraction drives the 3D patterning of epithelial cell surfaces.The Journal of cell biology · 2020Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Apical projections are integral functional units of epithelial cells. Microvilli and stereocilia are cylindrical apical projections that are formed of bundled actin. Microridges on the other hand, extend laterally, forming labyrinthine patterns on surfaces of various kinds of squamous epithelial cells. So far, the structural organization and functions of microridges have remained elusive. We have analyzed microridges on zebrafish epidermal cells using confocal and electron microscopy methods including electron tomography, to show that microridges are formed of F-actin networks and require the function of the Arp2/3 complex for their maintenance. During development, microridges begin as F-actin punctae showing signatures of branching and requiring an active Arp2/3 complex. Using inhibitors of actin polymerization and the Arp2/3 complex, we show that microridges organize the surface glycan layer. Our analyses have unraveled the F-actin organization supporting the most abundant and evolutionarily conserved apical projection, which functions in glycan organization.
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