Evidence map›Paper›PMID 31434914›Full record

ArticleScientific reports2019

Specimen Collection for Translational Studies in Hidradenitis Suppurativa.

A S Byrd, Y Dina, U J Okoh, Q Q Quartey, C Carmona-Rivera, D W Williams, M L Kerns, R J Miller, L Petukhova, H B Naik and 19 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. [Clinical, pathology-associated and molecular biomarkers of hidradenitis suppurativa/acne inversa].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 13 institutions in 3 countries.

A S ByrdDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA. angel_byrd@alumni.brown.edu.ORCID http://orcid.org/0000-0001-5358-4247
Y DinaMeharry Medical College, Nashville, TN, 37208, USA.
U J OkohDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Q Q QuarteyUniversity of Maryland School of Medicine, Baltimore, MD, 21201, USA.
C Carmona-RiveraSystemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0002-7706-1464
D W WilliamsDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
M L KernsDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
R J MillerDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.ORCID http://orcid.org/0000-0002-7662-6136
L PetukhovaDepartments of Dermatology and Epidemiology, Columbia University, New York, NY, 10032, USA.
H B NaikProgram for Clinical Research, Department of Dermatology, University of California San Francisco, San Francisco, CA, 94143-0808, USA.
L A BarnesStanford University School of Medicine, Stanford, CA, 94305, USA.
W D ShipmanWeill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program, New York, NY, 10065, USA.
J A CaffreyDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
J M SacksDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
S M MilnerDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
O AliuDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
K P BroderickDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
D KimDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
H LiuDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
C A DillenDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
R AhnDepartment of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, 90095, USA.ORCID http://orcid.org/0000-0002-9698-2752
J W FrewDepartment of Dermatology, Liverpool Hospital, Sydney, NSW, 2170, Australia.
M J KaplanSystemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
S KangDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
L A GarzaDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.ORCID http://orcid.org/0000-0002-6547-9695
L S MillerDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
A AlaviDepartment of Medicine (Dermatology), University of Toronto, Toronto, Ontario, M1C 1A4, Canada.
M A LowesThe Rockefeller University, New York, NY, 10065, USA.
G A OkoyeDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Johns Hopkins University · USHoward University · USNational Institutes of Health · USColumbia University · USCornell University · USLiverpool Hospital · AUMeharry Medical College · USRockefeller University · USStanford University · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Maryland, Baltimore · USUniversity of Toronto · CA

Funding

Systemic AutoimmunityZIAAR041199 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KAPLAN, MARIANA · 2014 to 2025
$32.5M
NIAMS Light Imaging FacilityZICAR041186 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI RANDAZZO, DAVIDE · 2010 to 2025
$18.2M
Towards the clinical testing of dsRNA to promote wound induced hair neogenesisR01AR068280 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI GARZA, LUIS ANDRES · 2016 to 2018
$718k
Intramural NIH HHS ZIA AR041199NIAMS NIH HHS R01 AR068280
6 · The paper itself

Abstract

Hidradenitis suppurativa (HS) is a chronic inflammatory disorder characterized by painful nodules, sinus tracts, and scars occurring predominantly in intertriginous regions. The prevalence of HS is currently 0.053-4%, with a predominance in African-American women and has been linked to low socioeconomic status. The majority of the reported literature is  retrospective, population based, epidemiologic studies. In this regard, there is a need to establish a repository of biospecimens, which represent appropriate gender and racial demographics amongst HS patients. These efforts will diminish knowledge gaps in understanding the disease pathophysiology. Hence, we sought to outline a step-by-step protocol detailing how we established our HS biobank to facilitate the formation of other HS tissue banks. Equipping researchers with carefully detailed processes for collection of HS specimens would accelerate the accumulation of well-organized human biological material. Over time, the scientific community will have access to a broad range of HS tissue biospecimens, ultimately leading to more rigorous basic and translational research. Moreover, an improved understanding of the pathophysiology is necessary for the discovery of novel therapies for this debilitating disease. We aim to provide high impact translational research methodology for cutaneous biology research and foster multidisciplinary collaboration and advancement of our understanding of cutaneous diseases.

Indexed as

Biological Specimen BanksHidradenitis SuppurativaProteomicsSpecimen HandlingTranslational Research, BiomedicalBlack or African AmericanFemaleHumansMaleRetrospective Studies

Identifiers

PMID31434914
PMCPMC6704132
OpenAlexW2969440303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.