Evidence map›Paper›PMID 31434912›Full record

ArticleScientific reports2019

Differential fracture response to traumatic brain injury suggests dominance of neuroinflammatory response in polytrauma.

Kazuhito Morioka, Yotvat Marmor, Jeffrey A Sacramento, Amity Lin, Tiffany Shao, Katherine R Miclau, Daniel R Clark, Michael S Beattie, Ralph S Marcucio, Theodore Miclau and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Beyond the initial impact: a systematic review of post-traumatic bone loss and its mechanisms.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Pooled it
  2. Article
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  5. Relationship between serum β-catenin mRNA expression and femoral fracture healing after head trauma: an experimental rat study.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026
    Article
  6. Article
  7. Review
  8. Review
  9. Article
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  11. [Research progress on mechanism of traumatic brain injury promoting fracture healing].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kazuhito MoriokaWeill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital (ZSFG), 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA, 94110, USA.ORCID http://orcid.org/0000-0001-5407-8178
Yotvat MarmorOrthopaedic Trauma Institute, Department of Orthopaedic Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital (ZSFG), 2550 23rd Street, Building 9, 3rd Floor, San Francisco, CA, 94110, USA.
Jeffrey A SacramentoWeill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital (ZSFG), 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA, 94110, USA.
Amity LinWeill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital (ZSFG), 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA, 94110, USA.
Tiffany ShaoOrthopaedic Trauma Institute, Department of Orthopaedic Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital (ZSFG), 2550 23rd Street, Building 9, 3rd Floor, San Francisco, CA, 94110, USA.
Katherine R MiclauOrthopaedic Trauma Institute, Department of Orthopaedic Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital (ZSFG), 2550 23rd Street, Building 9, 3rd Floor, San Francisco, CA, 94110, USA.
Daniel R ClarkOrthopaedic Trauma Institute, Department of Orthopaedic Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital (ZSFG), 2550 23rd Street, Building 9, 3rd Floor, San Francisco, CA, 94110, USA.
Michael S BeattieWeill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital (ZSFG), 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA, 94110, USA.
Ralph S MarcucioOrthopaedic Trauma Institute, Department of Orthopaedic Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital (ZSFG), 2550 23rd Street, Building 9, 3rd Floor, San Francisco, CA, 94110, USA.
Theodore MiclauOrthopaedic Trauma Institute, Department of Orthopaedic Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital (ZSFG), 2550 23rd Street, Building 9, 3rd Floor, San Francisco, CA, 94110, USA.
Adam R FergusonWeill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital (ZSFG), 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA, 94110, USA.ORCID http://orcid.org/0000-0001-7102-1608
Jacqueline C BresnahanWeill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital (ZSFG), 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA, 94110, USA. Jacqueline.Bresnahan@ucsf.edu.
Chelsea S BahneyOrthopaedic Trauma Institute, Department of Orthopaedic Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital (ZSFG), 2550 23rd Street, Building 9, 3rd Floor, San Francisco, CA, 94110, USA. cbahney@sprivail.org.

Funding

Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kate Taylor Shumate · 1999 to 2026
$209.7M
UCSF Core Center for Musculoskeletal Biology and MedicineP30AR066262 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOTZ, JEFFREY C. · 2014 to 2018
$3.0M
Translational Outcomes Project: Visualizing Syndromic Information and Outcomes for Neurotrauma (TOP-VISION)UG3NS106899 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BEATTIE, MICHAEL S, BRESNAHAN, JACQUELINE C · 2018 to 2019
$480k
A Murine Model of Polytrauma: Understanding the molecular basis of accelerated bone repair with concomitant traumatic brain injuryR21AR066847 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRESNAHAN, JACQUELINE C, MICLAU, THEODORE · 2015 to 2016
$383k
NCI NIH HHS P30 CA082103NIAMS NIH HHS P30 AR066262NIAMS NIH HHS R21 AR066847NINDS NIH HHS UG3 NS106899RRD VA I01 RX002787
6 · The paper itself

Abstract

Polytraumatic injuries, specifically long bone fracture and traumatic brain injury (TBI), frequently occur together. Clinical observation has long held that TBI can accelerate fracture healing, yet the complexity and heterogeneity of these injuries has produced conflicting data with limited information on underlying mechanisms. We developed a murine polytrauma model with TBI and fracture to evaluate healing in a controlled system. Fractures were created both contralateral and ipsilateral to the TBI to test whether differential responses of humoral and/or neuronal systems drove altered healing patterns. Our results show increased bone formation after TBI when injuries occur contralateral to each other, rather than ipsilateral, suggesting a role of the nervous system based on the crossed neuroanatomy of motor and sensory systems. Analysis of the humoral system shows that blood cell counts and inflammatory markers are differentially modulated by polytrauma. A data-driven multivariate analysis integrating all outcome measures showed a distinct pathological state of polytrauma and co-variations between fracture, TBI and systemic markers. Taken together, our results suggest that a contralateral bone fracture and TBI alter the local neuroinflammatory state to accelerate early fracture healing. We believe applying a similar data-driven approach to clinical polytrauma may help to better understand the complicated pathophysiological mechanisms of healing.

Indexed as

AnimalsBrain Injuries, TraumaticDisease Models, AnimalFractures, BoneMaleMiceMultiple Trauma

Identifiers

PMID31434912
PMCPMC6704103

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.