ArticleCell and tissue research1988
Adherens junctions in the ocular lens of various species: ultrastructural analysis with an improved fixation.
Article in Cell and tissue research, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 61 citations in OpenAlex.
- Hypoxia-Driven Histone Modifications Govern Gene Regulation for Mature Eye Lens Formation.Investigative ophthalmology & visual science · 2025Article
- Depth and Strain-Dependent Structural Responses of Mouse Lens Fiber Cells During Whole Lens Shape Changes.Investigative ophthalmology & visual science · 2025Article
- Arvcf Dependent Adherens Junction Stability is Required to Prevent Age-Related Cortical Cataracts.Frontiers in cell and developmental biology · 2022Article
- Spatially Resolved Proteomic Analysis of the Lens Extracellular Diffusion Barrier.Investigative ophthalmology & visual science · 2021Article
- Age-related changes in eye lens biomechanics, morphology, refractive index and transparency.Aging · 2019Article
- The molecular mechanisms underlying lens fiber elongation.Experimental eye research · 2017Review
- The lens actin filament cytoskeleton: Diverse structures for complex functions.Experimental eye research · 2017Review
- Breakdown of interlocking domains may contribute to formation of membranous globules and lens opacity in ephrin-A5(-/-) mice.Experimental eye research · 2016Article
- Regional changes of AQP0-dependent square array junction and gap junction associated with cortical cataract formation in the Emory mutant mouse.Experimental eye research · 2014Article
- Ultrastructural analysis of the human lens fiber cell remodeling zone and the initiation of cellular compaction.Experimental eye research · 2013Article
- Biological glass: structural determinants of eye lens transparency.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- Gap junctions are selectively associated with interlocking ball-and-sockets but not protrusions in the lens.Molecular vision · 2010Article
- Distribution of basal membrane complex components in elongating lens fibers.Molecular vision · 2008Article
- The role of the lens actin cytoskeleton in fiber cell elongation and differentiation.Seminars in cell & developmental biology · 2006Review
- ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory.Molecular and cellular biology · 2004Article
- Galectin-3 is associated with the plasma membrane of lens fiber cells.Investigative ophthalmology & visual science · 2000Article
- Nature and localization of avian lens glycogen by electron microscopy and Raman spectroscopy.Biophysical journal · 1992Article
- N-cadherin detected in the membrane fraction of lens fiber cells.Experientia · 1990Article
- Visualization of crystallin droplets associated with cold cataract formation in young intact rat lens.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The ultrastructure and distribution of adherens junctions in the intact adult lens of human, chicken, dove, rat, and rainbow trout were studied with thin-section electron microscopy, using an improved fixation containing a mixture of glutaraldehyde, lysine, and tannic acid. The nature of adherens junctions in the fiber-cells of the lens was also verified by immunofluorescence and rhodamine-phalloidin labelings for vinculin and actin. Electron microscopy revealed that adherens junctions of the lens were different ultrastructurally from the desmosomes found only between the lateral epithelial cells of the lens. The adherens junctions had the same structural characteristics as the zonulae adherentes, except that they were macular contacts, not belts. However, cross bridges were evident within the interspace of the junctions. Adherens junctions were located between the fiber-cells, between the epithelial cells and fiber-cells, and between the epithelial cells. They had a characteristic distribution in the "intersections" where three hexagonal fiber-cells met, as seen in cross-sections in all species studied. In addition, adherens junctions and associated actin were found distributed randomly along the entire cell membranes of both wide and narrow sides of cortical fiber-cells in the human, chicken, and dove lenses which have good accomodating capability. However, in the poorly-accomodating lenses of rat and fish, these junctions were seen predominantly on the narrow sides and at the regions of the wide sides that were very close to the "intersections". It is suggested that adherens junctions and associated actin microfilaments are involved in stabilizing the structural integrity of lens cells during accomodation and in preserving a specific lens shape.
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