Evidence map›Paper›PMID 31434788›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown.

Alex J Vecchio, Robert M Stroud

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 66 citations in OpenAlex.

  1. Review
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  7. "Design principles of a membrane-spanning ubiquitin ligase".bioRxiv : the preprint server for biology · 2025
    Article
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  11. Computational and structural biotechnology journal · 2025
    Article
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  13. The biology and pathogenicity ofMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  14. Review
  15. Article
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  18. Article
  19. Structural Basis ofToxins · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alex J VecchioDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA 94158.ORCID 0000-0002-4222-7874
Robert M StroudDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA 94158 stroud@msg.ucsf.edu.
University of California, San Francisco · US

Funding

STRUCTURE/FUNCTION OF PROTEINS AT MOLECULAR LEVELR01GM024485 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STROUD, ROBERT M · 1985 to 2024
$7.5M
Structural and Functional Investigation of Tight Junction Membrane ProteinsF32GM103277 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VECCHIO, ALEX J. · 2012 to 2014
$156k
NIGMS NIH HHS F32 GM103277NIGMS NIH HHS R01 GM024485
6 · The paper itself

Abstract

The human pathogenic bacterium

Indexed as

AnimalsBinding SitesClaudinsEnterotoxinsHumansIntestinal MucosaMiceModels, BiologicalModels, MolecularProtein BindingProtein ConformationStructure-Activity RelationshipTight JunctionsToxins, BiologicalClaudinsCLDN9 protein, humanenterotoxin, ClostridiumEnterotoxinsToxins, Biologicalclaudinmembrane proteintight junctiontoxinX-ray structure

Identifiers

PMID31434788
PMCPMC6731655
OpenAlexW2969626245

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.