Evidence map›Paper›PMID 31434749›Full record

ArticlemSphere2019

Environmental Persistence of Influenza Viruses Is Dependent upon Virus Type and Host Origin.

Karen A Kormuth, Kaisen Lin, Zhihong Qian, Michael M Myerburg, Linsey C Marr, Seema S Lakdawala

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Article
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  5. Article
  6. Article
  7. Article
  8. Article
  9. Fatal Human H3N8 Influenza Virus has a Moderate Pandemic Risk.bioRxiv : the preprint server for biology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Karen A KormuthDepartment of Microbiology & Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Kaisen LinDepartment of Civil and Environmental Engineering, Virginia Tech, Blacksburg, Virginia, USA.
Zhihong QianDepartment of Microbiology & Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Michael M MyerburgDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Linsey C MarrDepartment of Civil and Environmental Engineering, Virginia Tech, Blacksburg, Virginia, USA.
Seema S LakdawalaDepartment of Microbiology & Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA lakdawala@pitt.edu.
University of Pittsburgh · USVirginia Tech · USTsinghua University · CN

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
Viral Persistence and PathogenesisT32AI049820 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DELUCA, NEAL A. · 2001 to 2024
$5.5M
The Role of Pathogen-Environment Interactions in the Pandemic Potential of InfluenzaDP2AI112243 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI MARR, LINSEY · 2013 to 2016
$2.4M
Visualization of Influenza Viral RNA AssemblyR01AI139063 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LAKDAWALA, SEEMA S. · 2018 to 2022
$1.9M
Visualizing Influenza Viral RNA PackagingK22AI108600 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LAKDAWALA, SEEMA S. · 2016 to 2017
$266k
NCATS NIH HHS UL1 TR001857NIAID NIH HHS DP2 AI112243NIAID NIH HHS K22 AI108600NIAID NIH HHS R01 AI139063NIAID NIH HHS T32 AI049820
6 · The paper itself

Abstract

Highly transmissible influenza viruses (IV) must remain stable and infectious under a wide range of environmental conditions following release from the respiratory tract into the air. Understanding how expelled IV persist in the environment is critical to limiting the spread of these viruses. Little is known about how the stability of different IV in expelled aerosols is impacted by exposure to environmental stressors, such as relative humidity (RH). Given that not all IV are equally capable of efficient airborne transmission in people, we anticipated that not all IV would respond uniformly to ambient RH. Therefore, we have examined the stability of human-pathogenic seasonal and avian IV in suspended aerosols and stationary droplets under a range of RH conditions. H3N2 and influenza B virus (IBV) isolates are resistant to RH-dependent decay in aerosols in the presence of human airway surface liquid, but we observed strain-dependent variations in the longevities of H1N1, H3N2, and IBV in droplets. Surprisingly, low-pathogenicity avian influenza H6N1 and H9N2 viruses, which cause sporadic infections in humans but are unable to transmit person to person, demonstrated a trend toward increased sensitivity at midrange to high-range RH. Taken together, our observations suggest that the levels of vulnerability to decay at midrange RH differ with virus type and host origin.

Indexed as

Environmental MicrobiologyHost-Pathogen InteractionsMicrobial ViabilityAerosolsAnimalsBirdsHumansHumidityInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeInfluenza A Virus, H9N2 SubtypeInfluenza, HumanInfluenza in BirdsOrthomyxoviridaeTemperatureAerosolsaerosolsdropletsinfluenza viruspersistencerelative humidity

Identifiers

PMID31434749
PMCPMC6706471
OpenAlexW2969866910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.