Evidence map›Paper›PMID 31434747›Full record

ArticlemSphere2019

Trypanosoma brucei L11 Is Essential to Ribosome Biogenesis and Interacts with the Kinetoplastid-Specific Proteins P34 and P37.

Daniel Jaremko, Martin Ciganda, Linda Christen, Noreen Williams

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  6. Article
  7. Interactions of theParasitology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Daniel JaremkoDepartment of Microbiology and Immunology, University at Buffalo, Buffalo, New York, USA.
Martin CigandaDepartment of Microbiology and Immunology, University at Buffalo, Buffalo, New York, USA.
Linda ChristenDepartment of Microbiology and Immunology, University at Buffalo, Buffalo, New York, USA.
Noreen WilliamsDepartment of Microbiology and Immunology, University at Buffalo, Buffalo, New York, USA nw1@buffalo.edu.
University at Buffalo, State University of New York · US

Funding

Ribosomal biogenesis in trypanosomesR01GM110227 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI WILLIAMS, NOREEN · 2014 to 2017
$1.2M
Targeting the trypanosomal preribosomal complexR01GM113890 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI WILLIAMS, NOREEN · 2015 to 2018
$1.1M
Identifying Critical Interactions in the Unique Trypanosoma brucei 5S Ribonucleoprotein Complex and their Role in Ribosome BiogenesisF30GM125117 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI JAREMKO, DANIEL · 2017 to 2020
$160k
NIGMS NIH HHS F30 GM125117NIGMS NIH HHS R01 GM110227NIGMS NIH HHS R01 GM113890
6 · The paper itself

Abstract

Eukaryotic ribosome biogenesis is an essential cellular process involving tightly coordinated assembly of multiple rRNA and protein components. Much of our understanding of this pathway has come from studies performed with yeast model systems. These studies have identified critical checkpoints in the maturation of the large ribosomal subunit (LSU/60S), one of which is the proper formation and incorporation of the 5S ribonucleoprotein complex (5S RNP). Research on the 5S RNP has identified a complex containing the four proteins L5, L11, Rpf2, and Rrs1 as well as 5S rRNA. Our laboratory has studied the 5S RNP in

Indexed as

Organelle BiogenesisRibosomesProtein BindingRibosomal ProteinsRNA-Binding ProteinsRNA, Ribosomal, 5STrypanosoma brucei bruceip34 protein, Trypanosoma bruceip37 protein, Trypanosoma bruceiribosomal protein L11Ribosomal ProteinsRNA-Binding ProteinsRNA, Ribosomal, 5S5S rRNAL11protein-protein interactionsprotein-RNA interactionsribosomal proteinsribosome biogenesistrypanosomes

Identifiers

PMID31434747
PMCPMC6706469
OpenAlexW2969666555

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.