Evidence map›Paper›PMID 31434734›Full record

ArticleJournal of virology2019

The HIV-1 Antisense Protein ASP Is a Transmembrane Protein of the Cell Surface and an Integral Protein of the Viral Envelope.

Yvonne Affram, Juan C Zapata, Zahra Gholizadeh, William D Tolbert, Wei Zhou, Maria D Iglesias-Ussel, Marzena Pazgier, Krishanu Ray, Olga S Latinovic, Fabio Romerio

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
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  14. Creation of the HIV-1 antisense geneMicrobiology spectrum · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yvonne AfframInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Juan C ZapataInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Zahra GholizadehInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
William D TolbertInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Wei ZhouInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Maria D Iglesias-UsselInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Marzena PazgierInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Krishanu RayInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Olga S LatinovicInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Fabio RomerioInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA fromerio@ihv.umaryland.edu.
University of Maryland, Baltimore · US

Funding

Unlocking Envelope: A New Strategy for a Functional Cure Through Antibody-Dependent Cell-Mediated CytotoxicityR01AI129769 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PAZGIER, MARZENA ELZBIETA · 2017 to 2021
$2.3M
Quantification of the HIV-1 Reservoir by Immuno-PCRR01AI120008 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI HEREDIA, ALONSO, LICHTERFELD, MATHIAS · 2015 to 2019
$1.9M
Structural Targeting of Potentially Protective gp120 Epitopes in the C1/C2 RegionR01AI116274 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PAZGIER, MARZENA ELZBIETA · 2016 to 2019
$1.5M
Conformational Dynamics of HIV Envelope by Single Molecule SpectroscopyR01GM117836 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI RAY, KRISHANU · 2015 to 2018
$1.3M
PrimeFlow RNA for detection of latently-infected CD4+ T cellsR21AI124776 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI ROMERIO, FABIO · 2016 to 2017
$483k
Conformational Dynamics of HIV Envelope by Single Molecule SpectroscopyR01AI150447 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI RAY, KRISHANU · 2019 to 2019
$295k
NIAID NIH HHS R01 AI116274NIAID NIH HHS R01 AI120008NIAID NIH HHS R01 AI129769NIAID NIH HHS R01 AI150447NIAID NIH HHS R21 AI124776NIGMS NIH HHS R01 GM117836
6 · The paper itself

Abstract

The negative strand of HIV-1 encodes a highly hydrophobic antisense protein (ASP) with no known homologs. The presence of humoral and cellular immune responses to ASP in HIV-1 patients indicates that ASP is expressed

Indexed as

CD4-Positive T-LymphocytesCell LineCell MembraneCell NucleusHIV-1HIV Envelope Protein gp120HIV InfectionsHuman Immunodeficiency Virus ProteinsHumansLeukocytes, MononuclearProtein TransportViral Envelope ProteinsVirionASP protein, HIV-1HIV Envelope Protein gp120Human Immunodeficiency Virus ProteinsViral Envelope Proteinsantisense protein ASPcell surface proteinHIV-1viral envelope protein

Identifiers

PMID31434734
PMCPMC6803264
OpenAlexW2969878773

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.