Evidence map›Paper›PMID 31434732›Full record

ArticleJournal of virology2019

Murine Leukemia Virus Exploits Innate Sensing by Toll-Like Receptor 7 in B-1 Cells To Establish Infection and Locally Spread in Mice.

Ruoxi Pi, Akiko Iwasaki, Xaver Sewald, Walther Mothes, Pradeep D Uchil

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Ruoxi PiDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA.
Akiko IwasakiDepartment of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-7824-9856
Xaver SewaldMax von Pettenkofer Institute & Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany.
Walther MothesDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA walther.mothes@yale.edu pradeep.uchil@yale.edu.ORCID 0000-0002-3367-7240
Pradeep D UchilDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA walther.mothes@yale.edu pradeep.uchil@yale.edu.ORCID 0000-0002-7236-858X
Yale University · USGerman Center for Infection Research · DEHoward Hughes Medical Institute · US

Funding

Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI MEGAN C KING · 1985 to 2026
$85.0M
X-ray Cryst. CoreP50GM082545 · NIGMS · UNIVERSITY OF UTAH · PI SUNDQUIST, WESLEY I. · 2007 to 2018
$51.1M
Virus TransmissionP50AI150464 · NIAID · UNIVERSITY OF UTAH · PI SUNDQUIST, WESLEY I. · 2019 to 2021
$14.9M
Retrovirus cell-to-cell transmissionR01CA098727 · NCI · YALE UNIVERSITY · PI MOTHES, WALTHER H · 2003 to 2017
$4.5M
B cell based protection against recurrent herpesR01AI127429 · NIAID · YALE UNIVERSITY · PI IWASAKI, AKIKO · 2017 to 2021
$2.1M
A super-resolution microscope for research and educationS10OD020142 · OD · YALE UNIVERSITY · PI NATHANSON, MICHAEL H · 2015 to 2015
$600k
Howard Hughes Medical InstituteNCI NIH HHS P30 CA016359NCI NIH HHS R01 CA098727NIAID NIH HHS P50 AI150464NIAID NIH HHS R01 AI127429NIH HHS S10 OD020142
6 · The paper itself

Abstract

Lymph-borne Friend murine leukemia virus (FrMLV) exploits the sentinel macrophages in the draining popliteal lymph node (pLN) to infect highly permissive innate-like B-1 cells and establish infection in mice. The reason for FrMLV sensitivity of B-1 cells and their impact on viral spread is unknown. Here we demonstrate that Toll-like receptor 7 (TLR7) sensing and type I interferon (IFN-I) signaling in B-1 cells contribute to FrMLV susceptibility. FrMLV infection in B-1 cell-deficient mice (

Indexed as

Adoptive TransferAnimalsB-Lymphocyte SubsetsFriend murine leukemia virusImmunity, InnateInterferon Type ILymph NodesMembrane GlycoproteinsMiceMice, Inbred C57BLMice, Mutant StrainsRetroviridae InfectionsSignal TransductionToll-Like Receptor 7Tumor Virus InfectionsVirus ReplicationInterferon Type IMembrane GlycoproteinsTlr7 protein, mouseToll-Like Receptor 7B-1 cellsB-2 cellsbumble miceFrMLVpopliteal lymph noderetrovirusTLR7

Identifiers

PMID31434732
PMCPMC6803250
OpenAlexW2969347678

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.